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CCNE2 — E2F4

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: Complex of 14 proteins (association, anti tag coimmunoprecipitation) Litovchick et al., Mol Cell 2007
• IRef Intact Interaction: Complex of 13 proteins (association, anti bait coimmunoprecipitation) Litovchick et al., Mol Cell 2007
• IRef Intact Interaction: Complex of 14 proteins (association, anti bait coimmunoprecipitation) Litovchick et al., Mol Cell 2007

Text-mined interactions from Literome

Suzuki et al., Int J Cancer 2000 (Mouth Neoplasms...) : TSA enhanced the protein expression of p21 ( WAF1 ), CREB binding protein, cyclinE , cyclin A, Bak and Bax, while it reduced the expression of E2F-1, E2F-4 , HDAC1, p53 and hyperphosphorylated form of Rb
Duronio et al., Genes Dev 1995 : Instead, cyclin E expression activates E2F in the CNS
Chiarugi et al., Cell Mol Biol Res 1994 : Notably, both of the two giant regulators of checkpoint 1 ( i.e., p105RB [ retinoblastoma oncosuppressor encoded protein ] and p53 dependent WAF1/CIP1 ) are influenced by or influence G1 cyclins : cyclin E/cdk2 kinase complexes hyperphosphorylate p105RB, induce E2F release, and free G1 exit