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CASP12 — PARG
Text-mined interactions from Literome
Affar et al., J Biol Chem 2001
:
The cleavage sites identified by site directed mutagenesis are DEID ( 256 ) downward arrow V and the unconventional site MDVD ( 307 ) downward arrow N. Kinetic studies have shown similar maximal velocity ( V ( max ) ) and affinity ( K ( m ) ) for both full-length PARG and its apoptotic fragments, suggesting that
caspase-3 may
affect PARG function without altering its enzymatic activity
Feng et al., Molecular cancer 2012
(Breast Neoplasms) :
AIF silencing in these cells led to profound protection from chemotherapy, which demonstrates that the increased cell death after
PARG silencing and
caspase inhibition was mediated by AIF