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APP — NGFR
Pathways - manually collected, often from reviews:
-
NCI Pathway Database p75(NTR)-mediated signaling:
JNK family (MAPK8/MAPK9/MAPK10)
→
p75(NTR)/beta APP complex (NGFR-APP)
(modification, collaborate)
Troy et al., J Neurochem 2001, Yaar et al., J Biol Chem 2002
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database p75(NTR)-mediated signaling:
p75(NTR) (NGFR)
→
beta APP (APP)
(modification, collaborate)
Yaar et al., J Biol Chem 2002
Evidence: physical interaction, other species
-
NCI Pathway Database p75(NTR)-mediated signaling:
p75(NTR) (NGFR)
→
p75(NTR)/beta APP complex (NGFR-APP)
(modification, collaborate)
Yaar et al., J Biol Chem 2002
Evidence: physical interaction, other species
-
NCI Pathway Database p75(NTR)-mediated signaling:
beta APP (APP)
→
p75(NTR)/beta APP complex (NGFR-APP)
(modification, collaborate)
Yaar et al., J Biol Chem 2002
Evidence: physical interaction, other species
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Dip Interaction:
APP
—
NGFR
(direct interaction, pull down)
Nikolaev et al., Nature 2009*
-
IRef Dip Interaction:
APP
—
NGFR
(direct interaction, solid phase assay)
Nikolaev et al., Nature 2009*
-
IRef Intact Interaction:
APP
—
NGFR
(physical association, anti bait coimmunoprecipitation)
Yaar et al., J Biol Chem 2002
-
IRef Intact Interaction:
APP
—
NGFR
(direct interaction, enzyme linked immunosorbent assay)
Nikolaev et al., Nature 2009*
-
IRef Intact Interaction:
APP
—
NGFR
(direct interaction, pull down)
Nikolaev et al., Nature 2009*
Text-mined interactions from Literome
Wallace et al., Brain Res Mol Brain Res 1997
:
The neurotrophic activity of
APP was
independent of the TrkA
NGF receptor because neither phospholipase C-gamma1 nor TrkA exhibited tyrosine phosphorylations with APP treatment
Rossner et al., Prog Neurobiol 1998
(Alzheimer Disease) :
Recent experiments with NGF-responsive cells revealed a specific
role for the high-affinity
NGF receptor , TrkA, in the increases in secretory APP processing and a role for the low-affinity neurotrophin receptor, p75NTR, in the transcriptional regulation of
APP