◀ Back to SMAD4
IL11 — SMAD4
Text-mined interactions from Literome
Verrecchia et al., J Biol Chem 2003
:
We demonstrate that, in a cellular context devoid of JNK activity ( i.e. jnk ( -/- ) fibroblasts ),
interleukin-1 and tumor necrosis factor-alpha (TNF-alpha) did not
inhibit the formation of SMAD-DNA complexes and the resulting
SMAD-driven transcription in response to TGF-beta
Kang et al., Proc Natl Acad Sci U S A 2005
(Bone Neoplasms...) :
Genetic depletion experiments further demonstrate that
Smad4 contributes to the formation of osteolytic bone metastases and is
essential for the induction of
IL-11 , a gene implicated in bone metastasis in this mouse model system ... Activator protein-1 is a key participant in
Smad dependent transcriptional activation of
IL-11 and its overexpression in bone-metastatic cells
Kido et al., PloS one 2010
:
The present study was undertaken to clarify whether mechanical stress affects BMP-Smad signaling, and if so, to elucidate the
role of
Smad signaling in mechanical stress induced enhancement of
IL-11 gene transcription
Gupta et al., Cancer Biol Ther 2011
(Bone Neoplasms...) :
TGFß dependent induction of
interleukin-11 and interleukin-8
involves SMAD and p38 MAPK pathways in breast tumor models with varied bone metastases potential