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CDH5 — SLC22A3

Text-mined interactions from Literome

Timmerman et al., Genes Dev 2004 (Cell Transformation, Neoplastic) : Overexpression of N1IC in immortalized endothelial cells in vitro induces EMT accompanied by oncogenic transformation, with corresponding induction of snail and repression of VE-cadherin expression
Wendt et al., Oncogene 2010 (Breast Neoplasms...) : Mechanistically, EMT induced by TGF-ß increased cell-surface levels of EGFR and prevented its physical interaction with E-cadherin , leading instead to the formation of oncogenic signaling complexes with TßR-II
von Gise et al., Dev Biol 2011 : Although Wt1 has been proposed to regulate EMT by repressing E-cadherin , we detected no change in E-cadherin in Wt1 ( KO ) epicardium
Park et al., Dev Biol 2012 : Importantly, LIMK1 as well as cadherin-6B can trigger ectopic delamination when co-expressed with the competence factor SOX9, showing that this cadherin-6B stimulated signaling pathway can mediate the full EMT in the appropriate context