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RAC2 — VAV2

Pathways - manually collected, often from reviews:

• KEGG Focal adhesion: VAV1/VAV2/VAV3 → RAC1/RAC2/RAC3 (protein-protein, activation)
• KEGG Natural killer cell mediated cytotoxicity: VAV1/VAV2/VAV3 → RAC1/RAC2/RAC3 (protein-protein, activation)
• KEGG B cell receptor signaling pathway: VAV1/VAV2/VAV3 → RAC1/RAC2/RAC3 (protein-protein, activation)
• KEGG Fc epsilon RI signaling pathway: VAV1/VAV2/VAV3 → RAC1/RAC2/RAC3 (protein-protein, activation)
• KEGG Fc gamma R-mediated phagocytosis: VAV1/VAV2/VAV3 → RAC1/RAC2 (protein-protein, activation)
• KEGG Leukocyte transendothelial migration: VAV1/VAV2/VAV3 → RAC2 (protein-protein, activation)
• KEGG Regulation of actin cytoskeleton: TIAM1/TIAM2/VAV1/VAV2/VAV3 → RAC1/RAC2/RAC3 (protein-protein, activation)
• KEGG Chemokine signaling pathway: VAV1/VAV2/VAV3 → RAC1/RAC2 (protein-protein, activation)
• Reactome Reaction: RAC2 → VAV2 (reaction) Reid et al., J Biol Chem 1999, Schmidt et al., Genes Dev 2002, Jaffe et al., Annu Rev Cell Dev Biol 2005, Ramos-Morales et al., Oncogene 1995, Pasteris et al., Cell 1994, Hart et al., J Biol Chem 1994, Hart et al., J Biol Chem 1996, Zheng et al., J Biol Chem 1996, Van Aelst et al., Genes Dev 1997, Ren et al., J Biol Chem 1998
• WikiPathways Microglia Pathogen Phagocytosis Pathway: PLCG2/LAT/VAV1/VAV2/VAV3 → RAC1/RAC2/RAC3 (activation)
• WikiPathways Chemokine signaling pathway: VAV1/VAV2/VAV3 → RAC1/RAC2 (activation)

Text-mined interactions from Literome

Marignani et al., J Cell Biol 2001 : Vav2 nucleotide exchange is Src dependent in vivo, since the coexpression of Vav2 and dominant negative Src, or treatment with the Src inhibitor PP2, blocks both Vav2 dependent Rac activation and lamellipodia formation
Servitja et al., J Biol Chem 2003 (Cell Transformation, Neoplastic) : Evidence of a role for Tiam1 and Vav2 in Rac activation by Src
Marcoux et al., Oncogene 2003 : EGF receptor mediates adhesion dependent activation of the Rac GTPase : a role for phosphatidylinositol 3-kinase and Vav2
Murata et al., J Neurosci 2006 : These results indicate that CD47 promotes development of dendrites and axons in hippocampal neurons in a manner dependent, at least in part, on activation of Cdc42 and Rac mediated by Src as well as by FRG and Vav2
Yi et al., Cell Physiol Biochem 2007 : This Vav2-siRNA also blocked Rac activation induced by C16-Ceramide ( C16-Cer ), an intermediate lipid product stimulated by Hcys