Gene interactions and pathways from curated databases and text-mining

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CRK — PARP1

Text-mined interactions from Literome

Courtney et al., Eur J Neurosci 1999 : The death is accompanied by cleavage of the caspase substrate poly ADP ribose polymerase ( PARP ) and c-Abl dependent activation of the stress activated protein kinases c-Jun N-terminal kinase and p38
Mochizuki et al., J Biol Chem 2000 : We have found that R-Ras, but not Rap1 , mediates JNK activation by v-Crk in 293T and NIH 3T3 cells
Posern et al., Oncogene 2000 (MAP Kinase Signaling System) : We conclude that cellular Crk/CRKL complexes, recruited to upstream signaling components, contribute to basal and bombesin induced Rap1 activity, which is independent from the Ras-Raf-Erk pathway under these circumstances
Sawada et al., J Cell Sci 2001 (MAP Kinase Signaling System) : Rap1 is involved in cell stretching modulation of p38 but not ERK or JNK MAP kinase ... Furthermore, overexpression of Rap1 enhanced p38 activity but not ERK or JNK activity
Sakakibara et al., J Cell Sci 2002 : Novel function of Chat in controlling cell adhesion via Cas-Crk-C3G-pathway mediated Rap1 activation ... Certain Cas, Crk or C3G mutants suppressed Rap1 activation by Chat
Ling et al., J Biol Chem 2003 (MAP Kinase Signaling System) : Src-CrkII-C3G dependent activation of Rap1 switches growth hormone stimulated p44/42 MAP kinase and JNK/SAPK activities
Huang et al., J Biol Chem 2004 (MAP Kinase Signaling System) : Rap1 induced p38 mitogen activated protein kinase activation facilitates AMPA receptor trafficking via the GDI.Rab5 complex
Hattori et al., Gan To Kagaku Ryoho 1997 (Cell Transformation, Neoplastic) : [ Activation of Rap1 , antagonist to ras, by Crk-C3G ]