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ADAM10 — NOTCH2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Hartmann et al., Hum Mol Genet 2002
(Abnormalities, Multiple) :
In situ hybridization revealed a reduced expression of the Notch target gene hes-5 in the neural tube and an increased expression of the Notch ligand dll-1, supporting an important
role for
ADAM 10 in
Notch signalling in the vertebrates as well
Huovila et al., Trends Biochem Sci 2005
:
The recent studies have also begun to elucidate the substrate specificity and the mechanisms that control
ADAM mediated shedding events that regulate, for example, growth-factor and
Notch signalling, and the processing of the amyloid precursor protein
Dyczynska et al., J Biol Chem 2007
:
Our findings expand the
role of
ADAM proteins in the regulation of
Notch signaling
Muraguchi et al., Nat Neurosci 2007
:
These findings indicate that RECK is a physiological inhibitor of
ADAM10 , an upstream
regulator of
Notch signaling and a critical modulator of brain development
Zolkiewska et al., Cell Mol Life Sci 2008
:
ADAM mediated cleavage of
Notch represents the first step in regulated intramembrane proteolysis of the receptor, leading to activation of the Notch pathway
Tian et al., Int Immunol 2008
:
ADAM10 is
essential for proteolytic activation of
Notch during thymocyte development
Gibb et al., J Exp Med 2010
:
Thus,
ADAM10 critically
regulates MZB development by initiating
Notch2 signaling ... Thus,
ADAM10 critically
regulates MZB development by initiating
Notch2 signaling
Dornier et al., J Cell Biol 2012
:
The metalloprotease
ADAM10/Kuzbanian catalyzes the ligand dependent ectodomain shedding of Notch receptors and
activates Notch