◀ Back to LCK
LCK — SYK
Pathways - manually collected, often from reviews:
-
BioCarta il 2 signaling pathway:
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3/LCK/SYK complex (IL2-IL2RA-JAK3-JAK1-SYK-IL2RG-IL2RB-LCK)
→
SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1)
(modification, activates)
-
BioCarta il 2 signaling pathway:
SYK
→
LCK
(modification, collaborate)
-
BioCarta il 2 signaling pathway:
SYK
→
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3/LCK/SYK complex (IL2-IL2RA-JAK3-JAK1-SYK-IL2RG-IL2RB-LCK)
(modification, collaborate)
-
BioCarta il 2 signaling pathway:
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2)
→
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3/LCK/SYK complex (IL2-IL2RA-JAK3-JAK1-SYK-IL2RG-IL2RB-LCK)
(modification, collaborate)
-
BioCarta il 2 signaling pathway:
LCK
→
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3/LCK/SYK complex (IL2-IL2RA-JAK3-JAK1-SYK-IL2RG-IL2RB-LCK)
(modification, collaborate)
-
NCI Pathway Database Class I PI3K signaling events:
Src family/SYK family/BLNK-LAT complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT)
→
Src family/SYK family/BLNK-LAT/BTK-ITK complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK)
(modification, collaborate)
Shan et al., J Biol Chem 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Rawlings et al., Science 1996, August et al., Proc Natl Acad Sci U S A 1997
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database Class I PI3K signaling events:
Src family/SYK family/BLNK-LAT complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT)
→
BTK-ITK (ITK/BTK)
(modification, collaborate)
Shan et al., J Biol Chem 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Rawlings et al., Science 1996, August et al., Proc Natl Acad Sci U S A 1997
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database Class I PI3K signaling events:
Src family/SYK family/BLNK-LAT/BTK-ITK complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK)
→
BTK-ITK (ITK/BTK)
(modification, collaborate)
Shan et al., J Biol Chem 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Rawlings et al., Science 1996, August et al., Proc Natl Acad Sci U S A 1997
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database Class I PI3K signaling events:
None
→
Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK-PLCG1_PLCG2)
(modification, collaborate)
Rodriguez et al., Biochem J 2003
Evidence: mutant phenotype, other species
-
NCI Pathway Database Class I PI3K signaling events:
Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK-PLCG1_PLCG2)
(modification, activates)
Rodriguez et al., Biochem J 2003
Evidence: mutant phenotype, other species
-
NCI Pathway Database Class I PI3K signaling events:
Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK-PLCG1_PLCG2)
→
None
(modification, activates)
Rodriguez et al., Biochem J 2003
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL2-mediated signaling events:
SYK (SYK)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3)
(modification, collaborate)
Zhou et al., Mol Cell Biol 2000, Jiang et al., Blood 2003, Minami et al., Immunity 1995
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL2-mediated signaling events:
SYK (SYK)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SYK complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SYK)
(modification, collaborate)
Zhou et al., Mol Cell Biol 2000, Jiang et al., Blood 2003, Minami et al., Immunity 1995
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SYK complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SYK)
(modification, collaborate)
Zhou et al., Mol Cell Biol 2000, Jiang et al., Blood 2003, Minami et al., Immunity 1995
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Class I PI3K signaling events:
PLC-gamma family (PLCG1/PLCG2)
→
Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK-PLCG1_PLCG2)
(modification, collaborate)
Perez-Villar et al., J Immunol 1999, Rodriguez et al., Biochem J 2003, Serrano et al., J Immunol 2005
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database Class I PI3K signaling events:
PLC-gamma family (PLCG1/PLCG2)
→
Src family/SYK family/BLNK-LAT/BTK-ITK complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK)
(modification, collaborate)
Perez-Villar et al., J Immunol 1999, Rodriguez et al., Biochem J 2003, Serrano et al., J Immunol 2005
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database Class I PI3K signaling events:
Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK-PLCG1_PLCG2)
→
Src family/SYK family/BLNK-LAT/BTK-ITK complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK)
(modification, collaborate)
Perez-Villar et al., J Immunol 1999, Rodriguez et al., Biochem J 2003, Serrano et al., J Immunol 2005
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SYK complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SYK)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Jiang et al., Blood 2003
Evidence: mutant phenotype
-
Reactome Reaction:
SYK
→
LCK
(indirect_complex)
Jiang et al., J Immunol 2002, Moon et al., J Biol Chem 2005, Zou et al., Mol Cell 2008*, Brumbaugh et al., J Exp Med 1997, Lanier et al., Nature 1998, McVicar et al., J Biol Chem 1998
-
Reactome Reaction:
SYK
→
LCK
(reaction)
Zou et al., Mol Cell 2008*, Brumbaugh et al., J Exp Med 1997, Lanier et al., Nature 1998, McVicar et al., J Biol Chem 1998
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
LCK
—
SYK
(direct interaction, two hybrid)
Moon et al., J Biol Chem 2005
-
IRef Biogrid Interaction:
LCK
—
SYK
(physical association, affinity chromatography technology)
Thome et al., J Exp Med 1995*
-
IRef Biogrid Interaction:
LCK
—
SYK
(direct interaction, pull down)
Thome et al., J Exp Med 1995*
-
IRef Hprd Interaction:
LCK
—
SYK
(in vivo)
Thome et al., J Exp Med 1995*, Couture et al., J Biol Chem 1996*
-
IRef Intact Interaction:
LCK
—
SYK
(physical association, two hybrid)
Moon et al., J Biol Chem 2005
-
IRef Intact Interaction:
LCK
—
SYK
(association, coimmunoprecipitation)
Couture et al., J Biol Chem 1996*
-
IRef Intact Interaction:
LCK
—
SYK
(association, pull down)
Couture et al., J Biol Chem 1996*
-
IRef Intact Interaction:
LCK
—
SYK
(physical association, coimmunoprecipitation)
Panchamoorthy et al., J Biol Chem 1996
-
IRef Intact Interaction:
LCK
—
SYK
(physical association, two hybrid)
Couture et al., J Biol Chem 1996*
-
IRef Ophid Interaction:
LCK
—
SYK
(aggregation, confirmational text mining)
Panchamoorthy et al., J Biol Chem 1996
-
IRef Ophid Interaction:
LCK
—
SYK
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
LCK
—
SYK
(aggregation, confirmational text mining)
Thome et al., J Exp Med 1995*
Text-mined interactions from Literome
Chakraborty et al., J Biol Chem 2006
(Anoxia...) :
Accordingly, we hypothesized that hypoxia/reoxygenation ( H/R ) may play an important role in regulating
Syk activation, and
Lck may be
involved in this process
Couture et al., Mol Cell Biol 1994
:
Activation of
p56lck by
p72syk through physical association and N-terminal tyrosine phosphorylation ... Coexpression of lck did not alter the catalytic activity of p72syk, but the expressed
p56lck was much more active in the
presence of
p72syk than when expressed alone
Williams et al., Eur J Biochem 1997
:
We have previously reported that the activation of
Syk is less
dependent on the Src family kinase
Lck than the activation of Zap