UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to LCK

GNG2 — LCK

Pathways - manually collected, often from reviews:

NCI Pathway Database CXCR4-mediated signaling events: Src Family Kinases-active (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) → G beta/gamma complex (GNB1-GNG2) (modification, activates)
Wang et al., Blood 2000, Zhang et al., Blood 2001, Okabe et al., J Hematother Stem Cell Res 2002, Le et al., J Immunol 2005
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database CXCR4-mediated signaling events: G beta/gamma complex (GNB1-GNG2) → LCK (LCK) (modification, activates) Kumar et al., Immunity 2006, Patrussi et al., Blood 2007
Evidence: mutant phenotype, assay
NCI Pathway Database CXCR4-mediated signaling events: G beta/gamma complex (GNB1-GNG2) → TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247) (modification, activates)
Kumar et al., Immunity 2006, Patrussi et al., Blood 2007
Evidence: mutant phenotype, assay