Gene interactions and pathways from curated databases and text-mining

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IL22 — IRF3

Text-mined interactions from Literome

Mudter et al., Inflamm Bowel Dis 2011 (Colitis...) : In contrast to DSS colitis, IRF4 deficiency was protective in T-cell dependent transfer colitis associated with reduced RORa/?t levels and impaired IL-6, IL-17a, and IL-22 production, suggesting that IRF4 acts as a master regulator of mucosal Th17 cell differentiation
Ysebrant de Lendonck et al., Proc Natl Acad Sci U S A 2013 : Interferon regulatory factor 3 controls interleukin-17 expression in CD8 T lymphocytes