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CSF2 — IL12B
Text-mined interactions from Literome
Takayama et al., J Invest Dermatol 1999
:
Both
GM-CSF and TNF-alpha
induced the migration of human Langerhans cells in vitro, whereas IL-1beta, IL-2, IL-10,
IL-12 , and IFN-gamma had no effect on Langerhans cell migration
Tada et al., J Immunol 2000
:
Granulocyte/macrophage
colony stimulating factor inhibits
IL-12 production of mouse Langerhans cells ... Surprisingly,
GM-CSF strikingly
inhibited IL-12 p40 production by anti-CD40/IFN-gamma stimulated LC ( % inhibition = 97.0 +/- 0.9 % at 1 ng/ml GM-CSF ) ... IL-1alpha ( 1 ng/ml ) -stimulated KC produced much more
GM-CSF than unstimulated KC ( 60.9 +/- 0.2 pg/ml vs 20.9 +/- 1.7 pg/ml ), and IL-1alpha stimulated KC supernatants strongly
inhibited IL-12 p40 production by anti-CD40/IFN-gamma stimulated LC ( % inhibition = 89.4 +/- 1.4 % )
Tada et al., Eur J Immunol 2001
:
More importantly, it was found that in contrast to TGF-beta, granulocyte/macrophage
colony stimulating factor ( GM-CSF ) strikingly
inhibits IL-12 production of anti-CD40/IFN -- stimulated LC and that the level of LC IL-12 production is determined by the relative amounts of TGF-beta1 and GM-CSF
Dai et al., Immunology 2001
:
These findings demonstrated the ability of GL to enhance LPS induced IL-12 production by peritoneal macrophages, and indicated that the priming effect of GL on
IL-12 production was
independent of both IFN-gamma and
GM-CSF
Lissoni et al., J Biol Regul Homeost Agents 2001
(Neoplasms...) :
Stimulation of
IL-12 secretion by
GM-CSF in advanced cancer patients ... Unfortunately, at present there are only few and controversial results on
GM-CSF effects on
IL-12 secretion in cancer patients ... This preliminary study seems to show that
GM-CSF may acutely
stimulate IL-12 secretion in cancer patients ... Further studies are required to evaluate the effects of chronic GM-CSF administration, and the impact of
GM-CSF induced secretion of
IL-12 on the efficacy of the immunotherapies of cancer with cytokines, such as IL-2
Moore et al., J Virol 2002
:
IL-12 induced the greatest increase in IFN-gamma and immunoglobulin G responses to Nef, and
GM-CSF induced the strongest IFN-gamma and CTL responses to Env
Bolacchi et al., Cytokine 2001
:
Here we show that CD40L ( ligand for CD40 ) failed to induce the production of tumour necrosis factor alpha (TNF-alpha), interleukin (IL-)-1 beta, IL-10 and
IL-12 in macrophages matured in vitro in the absence of growth factors or in the
presence of macrophage
colony stimulating factor ( M-CSF )
Perez et al., Blood 2003
(Burkitt Lymphoma...) :
FL plus IL-15-driven ACF/CD56 ( + ) cells progressively expressed a mature NK functional program lysing both NK- and lymphokine-activate killer ( LAK ) -sensitive tumor targets and producing high levels of interferon-gamma (IFN-gamma), granulocyte-macrophage
colony stimulating factor , tumor necrosis factor alpha, and IL-10 upon
stimulation with
IL-12 and IL-18
Harada et al., J Interferon Cytokine Res 2004
:
In contrast, neutralizing
GM-CSF using anti-GM-CSF monoclonal antibody ( mAb ) significantly
inhibited IFN-gamma, TNF-alpha, and
IL-12p70 elicited by SCG
Li et al., Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 2004
(Malaria, Falciparum) :
GM-CSF , IL-4 and
IL-12 encoding plasmids all promoted mice immune response to VR1020/E, the antibody level
increased 7 to 10 times and splenocyte proliferation was enhanced too
Oishi et al., Cytokine 2006
:
The
rhG-CSF induced a pre-PHx downregulation of the
IL-12p70 protein levels, while also promoting the post-PHx reduction of the protein levels of IL-12p70 and IFN-gamma
Harada et al., Microbiol Immunol 2006
(Leukopenia) :
Neutralizing
GM-CSF significantly
inhibited the induction of IFN-gamma, TNF-alpha and
IL-12p70 by SCG
Eksioglu et al., Exp Hematol 2007
(Inflammation) :
We investigated the hypothesis that granulocyte-macrophage
colony stimulating factor ( GM-CSF )
induces IL-12 production and polarizes T lymphocytes toward a proinflammatory response
Ochoa-Repáraz et al., Infect Immun 2007
(Q Fever...) :
Cytokine analysis was performed on infected peritoneal macrophages isolated from these mice, and immunocompetent macrophages showed robust tumor necrosis factor alpha, IFN-gamma, and granulocyte-macrophage
colony stimulating factor ( GM-CSF ) but no
interleukin-12 (IL-12) responses
Nishimura et al., J Parasitol 2008
:
These results suggest that the WS
inhibits IL-12p40 mRNA production by promoting production of macrophage
colony stimulating factor by macrophages
Enríquez-de-Salamanca et al., Cytokine 2008
(Conjunctivitis, Allergic...) :
TNF-alpha stimulated secretion of
IL-12p40 was significantly
increased by 30 min ;
GM-CSF , MCP-1, IL-6, IL-7, IL-8, and RANTES were significantly increased by 2 h, and IFN-gamma and IL-1alpha by 24 h
Sonderegger et al., J Exp Med 2008
(Autoimmune Diseases...) :
We found that innate
GM-CSF was
critical for IL-6 and
IL-23 responses by dendritic cells and generation of pathological Th17 cells in vivo
Wong et al., J Immunol 2009
:
IL-12p70 production was produced predominantly by CD8alpha ( + ) DCs and plasmacytoid DCs, and
mediated by CD8 T cell derived cytokines IFN-gamma,
GM-CSF , TNF-alpha, and surface CD40L
van de Wetering et al., PloS one 2009
(Salmonella Infections) :
In addition,
IL-23 together with IL-18 or IL-1beta
led to the production of
GM-CSF in CD56 ( + ) cells ... Both IFN-gamma and
GM-CSF enhanced
IL-23 production by monocytes in response to TLR agonists, as well as induced IL-12 production
Martins et al., J Leukoc Biol 2011
:
GR-1 CM and
rG-CSF also
inhibited LPS induced
IL-12 production at the mRNA and protein levels
El-Behi et al., Nat Immunol 2011
(Encephalomyelitis, Autoimmune, Experimental) :
Here we found that
IL-23 induced production of the cytokine granulocyte-macrophage colony stimulating factor (
GM-CSF ) in T ( H ) 17 cells and that GM-CSF had an essential role in their encephalitogenicity ... IL-23 induced a positive feedback loop whereby
GM-CSF secreted by T ( H ) 17 cells
stimulated the production of
IL-23 by antigen presenting cells
Spear et al., J Immunol 2012
(Neoplasms, Experimental) :
T cell IFN-? and
GM-CSF activated local, tumor associated macrophages, decreased expression of regulatory factors,
increased IL-12p40 production, and augmented Ag processing and presentation by host macrophages to Ag-specific T cells
La Flamme et al., PloS one 2012
:
Instead, we found that derivation culture conditions ( GM-CSF plus IL-3 versus M-CSF ) could explain the different responses of BALB/c and IL-4Ra-/- macrophages, and these cytokines shaped the ensuing macrophage such that
GM-CSF plus IL-3
promoted more
IL-12 and IL-4 while M-CSF led to higher IL-10 production
Souza-Fonseca-Guimaraes et al., J Biol Chem 2013
(MAP Kinase Signaling System) :
Using knock-out-mice, we show that UNC93b1 and
IL-12 ( produced by NK cells themselves ) are also
necessary for IFN-? and
GM-CSF production
Kubin et al., J Exp Med 1994
:
The proliferative
effect of anti-CD28 and
IL-12 is resistant to moderate doses of cyclosporin A and is largely independent of endogenous IL-2, IL-12, in synergy with anti-CD28 or B7-transfected cells, is most effective in inducing interferon gamma (IFN-gamma) production, but production of tumor necrosis factor alpha and granulocyte/macrophage
colony stimulating factor is also observed
Cesano et al., Cancer Immunol Immunother 1995
:
CsA did not impair the ability of TALL-104 and LAK cells to produce interferon (IFN) gamma, tumor necrosis factor (TNF) alpha, and granulocyte/macrophage-colony-stimulatory factor (
GM-CSF ) in
response to IL-2,
IL-12 , or tumor targets
Aste-Amezaga et al., Cell Immunol 1994
:
It was found that
IL-12 induces mRNA accumulation and production of
GM-CSF and TNF-alpha from both T and NK cells and, as tested on NK cells only, induces M-CSF mRNA accumulation
Micallef et al., Eur J Immunol 1996
:
IGIF, but not
IL-12 , significantly
enhanced IL-2 and
GM-CSF production in T cell cultures, as determined by CTLL-2 bioassay and ELISA, respectively ; however, both IGIF and IL-12 enhanced IFN-gamma production by the T cells
Pulendran et al., J Immunol 1997
:
These DC subpopulations showed different capacities to phagocytose FITC-zymosan and to secrete
IL-12 upon
stimulation with Staphylococcus aureus cowan I strain + IFN-gamma +
granulocyte-macrophage-CSF
Okano et al., Int Arch Allergy Immunol 1998
(Asthma) :
We examined the
effects of
IL-12 on the productions of IL-5 and granulocyte/macrophage
colony stimulating factor ( GM-CSF ) by antigen ( Dermatophagoides farinae, Df ) -stimulated mononuclear cells ( MNCs ) from asthmatic patients in vitro ...
IL-12 enhanced IFN-gamma production and
inhibited the production of IL-5 but not of
GM-CSF by Df-stimulated MNCs from asthmatic patients
Grewe et al., J Immunol 1998
:
The expression of both
IL-12 protein and mRNAs for the p35 and p40 IL-12 subunits was strongly
induced in all donors by the Th2-like cytokines IL-4 and granulocyte-macrophage
CSF and was also moderately induced by TNF-alpha and IL-1alpha