Ulanova et al., Am J Physiol Lung Cell Mol Physiol 2005
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Syk mediated signaling regulates IL-6 and ICAM-1 expression and may be important in the pathophysiology of lung inflammation
Wang et al., J Immunol 2006
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ICAM-1 engagement by HRV and cross linking Abs also induced phosphorylation of p38 in a Syk dependent manner, and conversely, knockdown of Syk by short interfering ( si ) RNA substantially diminished p38 activation and IL-8 gene expression
Bijli et al., J Biol Chem 2008
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Activation of Syk by protein kinase C-delta regulates thrombin induced intercellular adhesion molecule-1 expression in endothelial cells via tyrosine phosphorylation of RelA/p65 ... In this study, we show that PKC-delta mediated activation of protein-tyrosine kinase Syk plays an important role in thrombin signaling of NF-kappaB activation and intercellular adhesion molecule-1 ( ICAM-1 ) expression in endothelial cells ... Consistent with this, thrombin induced NF-kappaB activity and ICAM-1 expression were prevented by the expression of a kinase-defective mutant or RNA interference knockdown of Syk