Gene interactions and pathways from curated databases and text-mining

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ICAM1 — IL1RN

Text-mined interactions from Literome

Yang et al., Brain Res Mol Brain Res 1999 (Arterial Occlusive Diseases...) : Since interleukin-1 can up-regulate intercellular adhesion molecules in endothelium, the present study was designed to determine whether overexpression of the IL-1ra can reduce the expression of intercellular adhesion molecule-1 ( ICAM-1 ) after ischemic injury
Zhu et al., Invest Ophthalmol Vis Sci 1999 (Corneal Neovascularization) : IL-1ra induced suppression of ICAM-1 expression was accompanied by a profound decrease in corneal leukocytic infiltration by 44.6 % at day 1 ( P < 0.003 ), 71.8 % at day 3 ( P < 0.001 ), 60.1 % at day 7 ( P < 0.001 ), and 63.8 % at day 14 ( P < 0.001 ), compared with control corneas
Wirjatijasa et al., J Neurosci Res 2002 : In summary, we demonstrate that IL-4, IL-10, and IL-1-ra induce microglial ramification and reduce ICAM-1-expression , whereas the secretion of proinflammatory cytokines is not prevented
Liu et al., Zhonghua Yan Ke Za Zhi 2003 (Graves Disease) : [ The inhibition effect of interleukin-1 receptor antagonist on interleukin-1 alpha induced intercellular adhesion molecule-1 expression on orbital fibroblasts and adhesion of peripheral blood mononuclear cells ] ... The aim was to identify whether interleukin-1 receptor antagonist ( IL-1ra ) inhibits interleukin-1 alpha (IL-1 alpha) induced intercellular adhesion molecule-1 ( ICAM-1 ) expression on cultured orbital fibroblasts, and adhesion of peripheral blood mononuclear cells ( PBMC ) to orbital fibroblasts, and to investigate the clinical application potential of IL-1ra in the treatment of Graves ' ophthalmopathy ( GO ) ... IL-1ra inhibits IL-1 alpha induced ICAM-1 expression in cultured orbital fibroblasts both from GO patients and controls ; IL-1ra inhibits IL-1 alpha induced adhesion of PBMC to orbital fibroblasts in a concentration and time dependent manner ... IL-1ra inhibits IL-1 alpha induced ICAM-1 expression in cultured orbital fibroblasts and the adhesion of PBMC to fibroblasts
Lee et al., Infect Immun 2005 (Periodontitis) : The increased ICAM-1 and IL-8 expression in the THP-1 cells obtained with rMsps was not inhibited in the presence of the IL-1 receptor antagonist (IL-1ra) , a natural inhibitor of IL-1
Salkind et al., J Clin Invest 1991 : These studies were undertaken to investigate effects of exposure and resultant net IL-1 inhibitor activity on the expression of the intercellular adhesion molecule-1 ( ICAM-1 ), and its ligand the lymphocyte function associated antigen ( LFA-1 )
Fischer et al., Immunol Cell Biol 2010 (Vascular Diseases) : Interestingly, overexpression of icIL-1ra also inhibited TNF induced upregulation of ICAM-1
Hong et al., J Neuroimmunol 1993 (Neuroblastoma) : The effects of a recombinant human interleukin-1 (IL-1) receptor antagonist ( IL-1ra ) and a recombinant human soluble IL-1 receptor ( sIL-1R ) on cytokine induced intercellular adhesion molecule-1 ( ICAM-1 ) expression in a human glioblastoma cell line and a neuroblastoma cell line were determined ... ICAM-1 expression induced by IL-1 beta, rabbit IL-1 beta 208-240 and human IL-1 beta 208-240 was blocked by the IL-1ra , while TNF alpha- and IFN gamma induced ICAM-1 expression were not
Burke-Gaffney et al., Am J Physiol 1996 : LPS induced ICAM-1 expression was not inhibited by interleukin-1 (IL-1) receptor antagonist ( 0.01-100 micrograms/ml )