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DDT — FOS
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Frigo et al., Environ Health Perspect 2002
:
Our results demonstrate that
DDT and dichlorodiphenyldichloroethane ( DDD ) were the most potent
activators of
AP-1 activity ; 2,2-bis ( p-chlorophenyl ) acetic acid failed to activate ... In addition,
DDT , DDD, and dichlorodiphenyldichloroethylene ( DDE ) could also
stimulate AP-1 activity in the estrogen-unresponsive human embryonic kidney 293 cells using a different promoter context
Han et al., Toxicol Appl Pharmacol 2008
:
Phosphatidylinositol 3 (PI3)-kinase, its downstream signaling molecule, Akt, and mitogen activated protein kinases ( MAPK ) were also significantly activated by the o,
p'-DDT induced
AP-1 and CRE activation