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EGFR — NRG1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of CTNNB1-EGFR → NRG1 (increases)
  Evidence: HRG treatment also promoted the level of tyrosine-phosphorylated beta -catenin associated with HER2, with a maximum effect detected at 15 min (Fig. 2B, lowest panel).
• BioCarta agrin in postsynaptic differentiation: EGF-R (EGFR) → neuregulin (NRG3/NRG2/NRG1) (modification, collaborate)
  
• BioCarta agrin in postsynaptic differentiation: EGF-R (EGFR) → neuregulin/ErbB1 complex (NRG3_NRG2_NRG1-EGFR) (modification, collaborate)
  
• BioCarta agrin in postsynaptic differentiation: neuregulin (NRG3/NRG2/NRG1) → neuregulin/ErbB1 complex (NRG3_NRG2_NRG1-EGFR) (modification, collaborate)
  
• NCI Pathway Database ErbB receptor signaling network: ErbB4/EGFR/neuregulin 1 beta complex (ERBB4-EGFR-NRG1) → ErbB4 (ERBB4) (modification, collaborate) Hobbs et al., Oncogene 2002, Cohen et al., J Biol Chem 1996
  Evidence: physical interaction
• NCI Pathway Database ErbB receptor signaling network: ErbB4/EGFR/neuregulin 1 beta complex (ERBB4-EGFR-NRG1) → neuregulin 1 beta (NRG1) (modification, collaborate) Hobbs et al., Oncogene 2002, Cohen et al., J Biol Chem 1996
  Evidence: physical interaction
• NCI Pathway Database ErbB receptor signaling network: ErbB4/EGFR/neuregulin 1 beta complex (ERBB4-EGFR-NRG1) → EGFR (EGFR) (modification, collaborate) Hobbs et al., Oncogene 2002, Cohen et al., J Biol Chem 1996
  Evidence: physical interaction
• NCI Pathway Database ErbB receptor signaling network: neuregulin 1 beta (NRG1) → EGFR (EGFR) (modification, collaborate) Hobbs et al., Oncogene 2002, Cohen et al., J Biol Chem 1996
  Evidence: physical interaction
• Reactome Reaction: EGFR → NRG1 (reaction) Vijapurkar et al., Exp Cell Res 2003, Walton et al., J Biol Chem 1990, Li et al., Cell Signal 2007, Xu et al., Mol Cell Biol 2007, Hazan et al., Cell Growth Differ 1990, Kaushansky et al., Chem Biol 2008, Helin et al., J Biol Chem 1991, Margolis et al., J Biol Chem 1989, Ricci et al., Oncogene 1995, Wallasch et al., EMBO J 1995, Prigent et al., EMBO J 1994, Soler et al., Oncogene 1994, Segatto et al., Oncogene 1993, Cohen et al., J Biol Chem 1996, Pinkas-Kramarski et al., EMBO J 1996
• Reactome Reaction: EGFR → NRG1 (indirect_complex) Cohen et al., J Biol Chem 1996

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: EGFR — NRG1 (physical association, affinity chromatography technology) Karunagaran et al., J Biol Chem 1995*

Text-mined interactions from Literome

Brinkmann et al., Neuron 2008 : It is thus thought that NRG1/ErbB signaling also regulates CNS myelination, a view suggested by in vitro studies and the overexpression of dominant negative ErbB receptors
Barros et al., Proc Natl Acad Sci U S A 2009 : Using CRE/LOX technology, we have inactivated ErbB2/B4 mediated NRG1 signaling specifically in the CNS ... We conclude that ErbB2/B4 mediated NRG1 signaling modulates dendritic spine maturation, and that defects at glutamatergic synapses likely contribute to the behavioral abnormalities in ErbB2/B4-deficient mice
Lopes-Conceição et al., Acta Med Port 2011 : The biological effects of NRG1 in the adult heart are mediated by the tyrosine kinase receptors ErbB
Kim et al., J Neurochem 2013 (MAP Kinase Signaling System) : Stimulation of the ErbB receptors by NRG1ß activated the phosphatidylinositol-3-kinase (PI3K) and mitogen activated protein kinase ( MAPK )
Iwakura et al., Frontiers in cellular neuroscience 2013 : ErbB1-4 dependent EGF/neuregulin signals and their cross talk in the central nervous system : pathological implications in schizophrenia and Parkinson 's disease