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CRH — CRHR2

Pathways - manually collected, often from reviews:

• Reactome Reaction: CRHR2 → CRH (direct_complex) Shibahara et al., EMBO J 1983*, Chen et al., Proc Natl Acad Sci U S A 1993*, Liaw et al., Endocrinology 1996*
• Reactome Reaction: CRHR2 → CRH (reaction) Wenzel-Seifert et al., Biochem Pharmacol 2002, Zhang et al., Eur J Pharmacol 2003, Lambert et al., Science signaling 2008, Mitsuhashi et al., J Biol Chem 1989, Kozasa et al., Proc Natl Acad Sci U S A 1988, Shibahara et al., EMBO J 1983*, Chen et al., Proc Natl Acad Sci U S A 1993*, Liaw et al., Endocrinology 1996*, Baker et al., J Biol Chem 1998
• WikiPathways Corticotropin-releasing hormone signaling pathway: CRHR2 → CRH (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CRH — CRHR2 (direct interaction, pull down) Perrin et al., Endocrinology 1993*
• IRef Ophid Interaction: CRHR2 — CRH (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Nozu et al., Am J Physiol 1999 (Intestinal Obstruction) : These results as well as earlier ones showing that alpha-helical CRF9-41 ( a CRF-R2 more selective antagonist ) partly prevented postoperative ileus indicate that peripheral CRF-R2 may be primarily involved in intravenous urocortin-, CRF- , and abdominal surgery induced gastric stasis
Pournajafi Nazarloo et al., Regul Pept 2003 : These data indicate : ( 1 ) that lack of CRH may decreases cardiac CRH-R2 mRNA expression in basal state, ( 2 ) that inhibitory effect of CRH deficiency on cardiac CRH-R2 mRNA expression in stress condition seems to be more closely linked to type of stressor than rise in plasma corticosterone level
Seres et al., J Clin Endocrinol Metab 2004 : CRH down-regulated CRH-R1 and CRH-R2 mRNA expression in isolated adipocytes
Maya-Núñez et al., Endocrine 2005 : CRH-stimulation of cyclic adenosine 5'-monophosphate pathway is partially inhibited by the coexpression of CRH-R1 and CRH-R2alpha
Kinsey-Jones et al., Stress 2006 : They also raise the possibility that up-regulation of CRF-R2 may contribute to the sensitising influence of E2 on CRF- and stress induced suppression of the GnRH pulse generator
Tezval et al., J Mol Histol 2009 (Bone Diseases, Metabolic) : The effects of UCN are mediated via stimulation of CRF-receptors 1 and 2 ( CRFR1 and 2, CRFR 's ) with a high affinity for CRFR2
Xu et al., Endocrinology 2011 : CRH acts on CRH-R1 and -R2 to differentially modulate the expression of large-conductance calcium activated potassium channels in human pregnant myometrium