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CDK2 — SP1
Pathways - manually collected, often from reviews:
-
FastForward regulation:
SP1
→
CDK2
(transcriptional regulation, unknown)
Evidence: DNABINDING, PROMACTIVITY
-
FastForward regulation:
SP1
→
CDK2
(transcriptional regulation, unknown)
Shiffman et al., J Biol Chem 1996*
Evidence: DNABINDING, PROMACTIVITY
-
FastForward regulation:
SP1
→
CDK2
(transcriptional regulation, unknown)
Xie et al., J Biol Chem 2003*, Shiffman et al., J Biol Chem 1996*
Evidence: DNABINDING, PROMACTIVITY
-
FastForward regulation:
SP1
→
CDK2
(transcriptional regulation, increase)
Shiffman et al., J Biol Chem 1996*
Evidence: DNABINDING, PROMACTIVITY
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Lu et al., Mol Endocrinol 2000
(Adenocarcinoma...) :
Androgen induction of
cyclin dependent kinase inhibitor p21 gene :
role of androgen receptor and transcription factor
Sp1 complex
Xie et al., J Biol Chem 2003
:
The tumor suppressor interferon regulatory factor 1 interferes with
SP1 activation to
repress the human
CDK2 promoter ... Mutation of this element abrogates
SP1 dependent enhancement of
CDK2 promoter activity as expected but also abolishes IRF1 mediated repression ... Forced elevation of
SP1 levels
increases endogenous
CDK2 levels, whereas IRF1 reduces both endogenous SP1 and CDK2 protein levels
Peñuelas et al., Eur J Biochem 2003
:
The expression of the transcription factor
Sp1 , a retinoblastoma interacting protein, was also
enhanced by all the
cyclin dependent kinase inhibitors tested
Banchio et al., J Biol Chem 2004
:
Sp1 binding is
enhanced by association with cyclin A/E and
CDK2 , both in vivo and in vitro
Chew et al., J Biol Chem 2012
:
Sulforaphane induction of p21 ( Cip1 )
cyclin dependent kinase inhibitor expression
requires p53 and
Sp1 transcription factors and is p53 dependent