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CCND1 — HRAS
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Matsumura et al., J Biol Chem 2000
:
We found that TPO stimulation or
Ha-Ras ( G12V ) expression
led to up-regulation of
cyclin D1 , cyclin D2, and cyclin D3 expression
Guillemot et al., J Biol Chem 2000
:
Using a pharmacological and a co-transfection approach, we found that
p21(ras) , Raf-1, phosphatidylinositol 3-kinase and also the catalytic activity of SHP-2 and its Src homology 2 domains are
required for
cyclin D1 promoter/reporter gene activation by Ang II through the regulation of MAPK/ERK activity
Sheng et al., J Biol Chem 2001
(Cell Transformation, Neoplastic) :
LY-294002 blocked the
Ha-Ras induced expression of
cyclin D1 , cyclin dependent kinase (CDK) 2, and increased the levels of p27 ( kip )
Guillemot et al., J Biol Chem 2001
(MAP Kinase Signaling System) :
Taken together, these findings demonstrate that Ang II-induced
cyclin D1 up-regulation is mediated by the activation and specific interaction of Egr-1 with the -136 to -96 bp region of the cyclin D1 promoter and by activation of the -29 to +139 bp region, both in a
p21(ras)/Raf-1/MEK/ERK dependent manner, and also involves PI3K and SHP-2
Kampfer et al., J Biol Chem 2001
:
Protein kinase C isoforms involved in the transcriptional
activation of
cyclin D1 by transforming
Ha-Ras ... The present investigations revealed that
cyclin D1 induction by transforming
Ha-Ras is MEK- and Rac dependent and requires the PKC isotypes epsilon, lambda, and zeta, but not cPKC-alpha ... This conclusion is based on observations indicating that
cyclin D1 induction by transforming
Ha-Ras was depressed in a dose dependent manner by PD98059, a selective inhibitor of the mitogen activated kinase kinase MEK-1, demonstrating that Ha-Ras employs extracellular signal regulated kinases ( ERKs ) for signal transmission to the cyclin D1 promoter
Janda et al., Oncogene 2002
(Neoplasms) :
Here, we demonstrate that oncogenic
Ha-Ras or constitutively active Her-2 cause
increased proliferation and
cyclin D1 upregulation in fully polarized, mammary epithelial cells ( EpH4 ), if cultivated as organotypic structures in three-dimensional collagen/matrigel matrices
Albanese et al., J Biol Chem 1995
:
Transforming
p21ras mutants and c-Ets-2
activate the
cyclin D1 promoter through distinguishable regions ... Site directed mutagenesis of AP-1-like sequences at -954 abolished
p21ras dependent activation of
cyclin D1 expression ... The
activation of
cyclin D1 transcription by
p21ras provides evidence for cross-talk between the p21ras and cell cycle regulatory pathways
Liu et al., Mol Cell Biol 1995
(Cell Transformation, Neoplastic) :
These results suggest that increased expression of
cyclin D1 is
necessary but not sufficient for the transforming activity of
v-H-Ras