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CCND1 — EGR1

Text-mined interactions from Literome

Guillemot et al., J Biol Chem 2001 (MAP Kinase Signaling System) : Taken together, these findings demonstrate that Ang II-induced cyclin D1 up-regulation is mediated by the activation and specific interaction of Egr-1 with the -136 to -96 bp region of the cyclin D1 promoter and by activation of the -29 to +139 bp region, both in a p21(ras)/Raf-1/MEK/ERK dependent manner, and also involves PI3K and SHP-2
Xiao et al., Cancer Res 2005 (MAP Kinase Signaling System...) : The induction of Egr-1 expression and its binding to the cyclin D1 promoter were essential for bombesin enhanced cyclin D1 transcription ... Taken together, bombesin induced cyclin D1 expression in prostate cancer cells is mediated by Egr-1 activation and the interaction of Egr-1 with the Egr-1/Sp1 motif of the cyclin D1 promoter through the activation of MAPK pathway
Wu et al., Braz J Med Biol Res 2010 (Hyperplasia) : Thus, ED5 can specifically inhibit Egr-1 expression, and probably inhibits VSMC proliferation by down regulating the expressions of cyclin D1 and TGF-beta1