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CASP3 — SP1

Pathways - manually collected, often from reviews:

• WikiPathways Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways: TP73/SP1 → CASP3 (mim-transcription-translation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: SP1 — CASP3 (direct interaction, enzymatic study) Rickers et al., Eur J Biochem 1999*
• IRef Hprd Interaction: SP1 — CASP3 (in vitro) Rickers et al., Eur J Biochem 1999*

Text-mined interactions from Literome

Miyoshi et al., Biochem Biophys Res Commun 2005 : Experiments using a GC-specific DNA binding agent, mithramycin A, and an electrophoretic mobility shift assay demonstrated that Sp1 might mediate the enhanced expression of caspase-3
Sudhakar et al., FEBS J 2008 : The caspase-3 promoter was activated by Sp1 in Sp1-deficient Drosophila SL-2 cells
Tu et al., J Mol Endocrinol 2013 : Additionally, this ERa-SP1 complex binds to the proximal and distal sites of the TNFa gene promoter and further induces the expression of active caspase 3 in a ligand dependent manner
Kikuchi et al., J Biol Chem 2013 (Multiple Myeloma) : K-7174 induces transcriptional repression of class I histone deacetylases ( HDAC1, -2, and -3 ) via caspase-8 dependent degradation of Sp1 , the most potent transactivator of class I HDAC genes