◀ Back to BRD4

BRD4 — CCNT1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind_translation Interaction: BRD4 — CCNT1 (coimmunoprecipitation) Jang et al., Mol Cell 2005
• IRef Bind_translation Interaction: BRD4 — CCNT1 (affinity chromatography technology) Jang et al., Mol Cell 2005
• IRef Bind_translation Interaction: BRD4 — CCNT1 (experimental interaction detection) Jang et al., Mol Cell 2005
• IRef Biogrid Interaction: BRD4 — CCNT1 (physical association, affinity chromatography technology) Rahman et al., Mol Cell Biol 2011
• IRef Biogrid Interaction: BRD4 — CCNT1 (physical association, affinity chromatography technology) Bisgrove et al., Proc Natl Acad Sci U S A 2007*
• IRef Biogrid Interaction: BRD4 — CCNT1 (direct interaction, pull down) Bisgrove et al., Proc Natl Acad Sci U S A 2007*
• IRef Biogrid Interaction: BRD4 — CCNT1 (physical association, affinity chromatography technology) Yang et al., Mol Cell 2005*
• IRef Biogrid Interaction: BRD4 — CCNT1 (physical association, affinity chromatography technology) Jang et al., Mol Cell 2005
• IRef Biogrid Interaction: BRD4 — CCNT1 (direct interaction, pull down) Jang et al., Mol Cell 2005
• IRef Biogrid Interaction: BRD4 — CCNT1 (physical association, affinity chromatography technology) Yang et al., Mol Cell Biol 2008*
• MIPS CORUM BRD4 complex: BRD4 complex complex (BRD4-CCNT1-CDK9-MED1-MED12-MED14-MED17-MED24) Jang et al., Mol Cell 2005
• MIPS CORUM P-TEFb-BRD4-TRAP220 complex: P-TEFb-BRD4-TRAP220 complex complex (BRD4-CCNT1-CDK9-MED1) Yang et al., Mol Cell 2005*
• MIPS CORUM BRD4-P-TEFb complex: BRD4-P-TEFb complex complex (BRD4-CCNT1-CDK9) Jang et al., Mol Cell 2005
• MIPS CORUM BRD4-P-TEFb complex: BRD4-P-TEFb complex complex (BRD4-CCNT1-CDK9) Yang et al., Mol Cell 2005*
• IRef Corum Interaction: Complex of MED14-BRD4-CCNT1-MED17-MED24-MED12-CDK9-MED1 (association, tandem affinity purification) Jang et al., Mol Cell 2005
• IRef Corum Interaction: Complex of CCNT1-BRD4-CDK9-MED1 (association, anti tag coimmunoprecipitation) Yang et al., Mol Cell 2005*
• IRef Dip Interaction: BRD4 — CCNT1 (direct interaction, anti tag coimmunoprecipitation) Bisgrove et al., Proc Natl Acad Sci U S A 2007*
• IRef Dip Interaction: BRD4 — CCNT1 (direct interaction, pull down) Bisgrove et al., Proc Natl Acad Sci U S A 2007*
• IRef Dip Interaction: Complex of MED13-CCNC-CDK9-MED15-CDK8-CCNT1-MED12-BRD4 (anti bait coimmunoprecipitation) Donner et al., Nature structural & molecular biology 2010
• Gene Ontology Complexes positive transcription elongation factor complex b: positive transcription elongation factor complex b complex (CCNT1-BRD4-SNW1) Brès et al., Genes Dev 2005*
• IRef Hprd Interaction: BRD4 — CCNT1 (in vivo) Jang et al., Mol Cell 2005
• IRef Hprd Interaction: Complex of 22 proteins (in vivo) Jang et al., Mol Cell 2005
• IRef Hprd Interaction: Complex of 57 proteins (in vivo) Jang et al., Mol Cell 2005

Text-mined interactions from Literome

Jang et al., Mol Cell 2005 : The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription ... An increase in Brd4 expression led to increased P-TEFb dependent phosphorylation of RNA polymerase II (RNAPII) CTD and stimulation of transcription from promoters in vivo
Zhou et al., J Virol 2009 : Here we provide evidence that Brd4 regulates P-TEFb kinase activity by inducing a negative pathway
Devaiah et al., J Biol Chem 2012 : The CTD Ser-5 kinase CDK7 also interacts with and phosphorylates BRD4 , potently inhibiting BRD4 kinase activity
Li et al., Nucleic Acids Res 2013 : The BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation ... Brd4 competitively blocks the Tat-SEC interaction on HIV promoter
Proserpio et al., Genes Dev 2013 (Muscular Atrophy) : Supporting functional relevance of the SMYD3/BRD4 interaction, BRD4 pharmacological blockade by the small molecule JQ1 prevents dexamethasone induced myostatin and atrogene up-regulation and spares myotube atrophy