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AKT1 — THPO
Text-mined interactions from Literome
Kroner et al., J Biol Chem 2000
:
alpha-Thrombin and
thrombopoietin activate
PKBalpha via PI-3K and trigger the concurrent phosphorylation of Thr ( 308 ) ( via PDK1 ) and Ser ( 473 ) ( via a not yet identified PDK2 )
Majka et al., Exp Hematol 2002
(MAP Kinase Signaling System) :
Thrombopoietin , but not cytokines binding to gp130 protein coupled receptors,
activates MAPKp42/44,
AKT , and STAT proteins in normal human CD34+ cells, megakaryocytes, and platelets
Kanaji et al., Blood 2004
(Thrombocytopenia) :
An observed increase in
thrombopoietin mediated
Akt phosphorylation in the truncated variant supported the hypothesis and led to the development of a model in which the GP Ibalpha cytoplasmic tail sequestered signaling proteins during megakaryocytopoiesis and, as such, became a critical regulator in the temporal sequence of events that led to normal megakaryocyte maturation
Kozuma et al., Journal of thrombosis and haemostasis : JTH 2007
:
Continuous expression of Bcl-xL protein during megakaryopoiesis is post-translationally regulated by
thrombopoietin mediated
Akt activation , which prevents the cleavage of Bcl-xL
Yamazaki et al., Curr Opin Hematol 2009
:
With the help of advances in confocal microscopy, laser scanning microscopy, and personal computer computational power over the last decade, it has become evident that
thrombopoietin/c-Mpl signaling
plays a role in HSC self-renewal and
AKT-forkhead box O signaling in HSC dormancy