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AKT1 — SPARC

Text-mined interactions from Literome

Shi et al., J Biol Chem 2004 (Glioma) : Exogenous SPARC rapidly induces AKT phosphorylation, an effect that is blocked by a neutralizing SPARC antibody
Shi et al., Oncogene 2007 (Brain Neoplasms...) : SPARC expression in glioma cells promotes invasion and survival under stress, the latter process dependent on SPARC activation of AKT ... Downregulation of either FAK or ILK expression inhibited SPARC mediated AKT phosphorylation, and targeting both FAK and ILK attenuated AKT activation more potently than targeting either FAK or ILK alone
Said et al., Am J Pathol 2007 (Neoplasm Invasiveness...) : Moreover, SPARC significantly suppressed both anchorage dependent and -independent activation of AKT and mitogen-acti vated protein kinase survival signaling pathways in ovarian cancer cells in response to serum and epidermal growth factor stimulation
Thomas et al., Neuro Oncol 2010 (Brain Neoplasms...) : PTEN augments SPARC suppression of proliferation and inhibits SPARC induced migration by suppressing SHC-RAF-ERK and AKT signaling
Fenouille et al., Oncogene 2011 (Melanoma) : Conversely, increased expression of SPARC stimulates Akt and MDM2 phosphorylation, thus facilitating p53 degradation
Bhoopathi et al., PloS one 2012 (Neuroblastoma) : SPARC overexpression inhibits cell proliferation in neuroblastoma and is partly mediated by tumor suppressor protein PTEN and AKT ... Additionally, SPARC overexpression significantly suppressed the activity of AKT and this suppression was accompanied by an increase in the tumor suppressor protein PTEN both in vitro and in vivo