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AKT1 — SP1
Text-mined interactions from Literome
Bae et al., Cancer Res 2006
(Adenocarcinoma...) :
The inhibition of
PI3K/Akt signaling also
prevented Sp1 activation
Jin et al., Cell Signal 2007
:
Also, suppression of
Akt activation
blocked the expression of Redd1 and the activation of HIF-1alpha and
Sp1 by CoCl ( 2 ) and HCD
Qureshi et al., Cell Signal 2007
:
Phosphatidylinositol kinase ( PI3K ) inhibitors, Wortmannin and LY294002 and
Akt inhibitor ( NL-71-101 ) significantly
inhibited TGF-beta induced Akt phosphorylation, TIMP-3 expression, TIMP-3 promoter ( -940 to +376 ) -driven luciferase activity and
Sp1 transcription factor binding
Pang et al., International journal of molecular sciences 2013
:
Furthermore, resistin enhanced DNA binding activity of
Sp1 with VEGF promoter in a
PI3K/Akt dependent manner ...
PI3K/Akt activated by resistin
led to increasing interaction with
Sp1 , triggering a progressive phosphorylation of Sp1 on Thr453 and Thr739, resulting in the upregulation of VEGF expression