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AKT1 — PARP1
Text-mined interactions from Literome
Tsygankova et al., Mol Cell Biol 2001
:
The ability of TSH to stimulate
Akt phosphorylation was markedly
enhanced by the expression of activated
Rap1A and was repressed in cells expressing a putative dominant negative Rap1A mutant ... Although the expression of activated
Rap1A was
sufficient to stimulate wortmannin-sensitive
Akt phosphorylation, TSH further increased Akt phosphorylation in a phosphatidylinositol 3-kinase- and PKA dependent manner
Wang et al., J Biol Chem 2001
:
Moreover, inhibition of
Rap1 by a Rap1 GTPase activating protein-1 also
resulted in a decrease in ERK and
Akt phosphorylation, which was not further decreased by cAMP, suggesting that cAMP inhibits ERK and Akt by inhibiting Rap1 ... The
role of
Rap1 in ERK and
Akt activity was further demonstrated by our observation that an active form of Epac, which activated Rap1 in the absence of cAMP, increased ERK and Akt phosphorylation
Grader-Beck et al., Blood 2003
:
Thus, TCR plus CD28 mediated activation of ERK1/2 and
PKB , cytokine production, and cell cycle progression, all of which are inhibited by cAMP,
require activation of Ras but not
Rap1
Tapodi et al., J Biol Chem 2005
(Necrosis) :
These data together with the finding that
PARP inhibition in the absence of oxidative stress
induced the phosphorylation and activation of
Akt indicate that PARP inhibition induced Akt activation is dominantly responsible for the cytoprotection in oxidative stress
Romano et al., Endocrinology 2006
:
Under the same conditions, PI3K and
Akt inhibition also both
increased Raf-1 kinase activity and the levels of GTP bound ( active form ) monomeric G protein
Rap1 , which suggests that a down-regulation of the ERK-1/2 cascade is induced by the PI3K/Akt signaling pathway in unstimulated cells
Mathews et al., Arterioscler Thromb Vasc Biol 2008
:
PARP-1 inhibition can also
activate the prosurvival serine/threonine kinase,
Akt ...
PARP-1 inhibition
increased Akt , BAD, and VEGFR2 phosphorylation in HUVECs and in PJ34 treated rabbit aortas
Pacurari et al., Environ Health Perspect 2008
(Neoplasms, Mesothelial) :
In the present study, we exposed mesothelial cells to SWCNTs and investigated reactive oxygen species ( ROS ) generation, cell viability, DNA damage, histone H2AX phosphorylation,
activation of
poly(ADP-ribose) polymerase 1 ( PARP-1 ), stimulation of extracellular signal regulated kinase ( ERKs ), Jun N-terminal kinases (JNKs), protein p38, and activation of activator protein-1 (AP-1), nuclear factor kappaB (NF-kappaB), and protein serine-threonine kinase (
Akt )
Szanto et al., Biochem Pharmacol 2009
:
To understand the
role of
Akt activation in the combined use of cytostatic agent and
PARP inhibition, we used taxol ( paclitaxel ) as an antineoplastic agent, which targets microtubules and up-regulates mitochondrial ROS production, together with ( i ) pharmacological inhibition ( PJ-34 ), ( ii ) siRNA knock-down and ( iii ) transdominant expression of the DNA binding domain of PARP-1
Edreira et al., J Biol Chem 2009
:
cAMP dependent protein kinase (PKA) mediated phosphorylation of
Rap1b is
required for cAMP dependent mitogenesis, tumorigenesis, and inhibition of
AKT activity
Gatson et al., Journal of neuroinflammation 2009
(Burns...) :
In addition, we determined that in the estrogen treated rats there was an increase in the levels of phospho-ERK ( p < 0.01 ) and
Akt ( p < 0.05 ) at the 24 hour time-point, and that 17 beta-estradiol
blocked the activation of caspase-3 ( p < 0.01 ) and subsequent cleavage of
PARP ( p < 0.05 )
Malchinkhuu et al., Mol Biol Cell 2009
(Glioma) :
The expression of tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 ( PTEN ) is required for the inhibitory ISO induced and
Rap1B mediated
actions on the migration, Rac1 activation, and
Akt activation in response to LPA
Mallon et al., Mol Cancer Ther 2010
:
We are testing whether dual PI3K/mTOR inhibitors can durably suppress
p-Akt ,
induce cleaved
PARP , and cause tumor regression in a diverse set of human tumor xenograft models
Tawa et al., Circ Res 2010
(Disease Models, Animal...) :
Rap1 regulated the interaction between afadin and phosphatidylinositol 3-kinase (PI3K), recruitment of the afadin-PI3K complex to the leading edge, and the activation of
Akt , indicating the involvement of Rap1 and afadin in the PI3K-Akt signaling pathway
Wang et al., Biochem Biophys Res Commun 2011
:
PARP1 inhibitors
attenuate AKT phosphorylation via the upregulation of PHLPP1