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AKT1 — ALK

Text-mined interactions from Literome

Bianco et al., Mol Cell Biol 2002 : In contrast, CR-1 stimulation of mitogen activated protein kinase and AKT in these cells is independent of Nodal and ALK4 , suggesting that CR-1 may modulate different signaling pathways to mediate its different functional roles
Osajima-Hakomori et al., Am J Pathol 2005 (Neuroblastoma) : The suppression of activated ALK in neuroblastoma cells by RNA interference significantly reduced the phosphorylation of ShcC, mitogen activated protein kinases, and Akt , inducing rapid apoptosis in the cells
Zhang et al., Diabetologia 2006 : Activation of ALK7 increased Smad2 phosphorylation, reduced protein kinase B ( Akt ) kinase activity and was associated with increased levels of the bioactive forms of caspase-3, whereas co-expression of constitutively active ALK7 with dominant negative Smad2 or constitutively active Akt significantly diminished ALK7 induced growth inhibition and apoptosis in INS-1 cells
Theodoraki et al., Exp Cell Res 2007 : The mechanism underlying the effect of NPM-ALK on Akt stability was probed by comparison of the turnover of the kinase after translation inhibition and geldanamycin treatment
Wong et al., Cancer 2011 (Adenocarcinoma...) : Overexpression of KIF5B-ALK in mammalian cells led to the activation of signal transducer and activator of transcription 3 and protein kinase B and to enhanced cell proliferation, migration, and invasion
Thakral et al., Pediatr Blood Cancer 2012 (Lymphoma, Large-Cell, Anaplastic) : Pharmacologic inhibition of activated ALK does not reduce modest levels of activated Akt as it does with the more abundant levels of activated STAT3 or STAT5