Lampasso et al., Int J Mol Med 2006
:
The inhibition of p38 resulted in a marked down-regulation of PKC eta Marchant et al., Circ Res 2009
(Cardiac Output, Low...) :
However, bosentan enhanced cardiac viral load ( 10.4+/-6.7 % in the bosentan group versus 5.0+/-5.5 % in control group ; P=0.02 ), likely through enhancement of p38 mitogen activated protein kinase ( MAPK ) phosphorylation ( 0.77+/-0.40 % ATF2 activation in the bosentan group versus 0.03+/-0.02 % in controls ; P=0.0002 ), mediated by endothelin receptor type-A