Di Segni et al., J Mol Neurosci 2006
:
Taken together, these results indicate that in PC12-ErbB4 cells, the NRG induced neuroprotective effect from MPP+ treatment, requires PI3K/PKB/Akt and Ras/MapK signaling networks
Bernard et al., J Biol Chem 2012
(Disease Models, Animal...) :
Furthermore, in contrast to related ligands, NRG4 enhanced cell survival but not proliferation or migration, and stimulated phosphorylation of the anti-apoptotic mediator Akt but not ERK MAPK