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EIF4E — NFKB1
Text-mined interactions from Literome
Yang et al., Chin J Cancer 2003
(Adenocarcinoma...) :
[
Role of
eukaryotic initiation factor-4E (eIF-4E) in regulation of expression of
NF-kappaB and its subsequent influence on transcription and activity of heparanase in human colon adenocarcinoma cell line ] ... The current study was designed to investigate the
effect of
eIF-4E on the expression and activity of
NF-kappaB and observe how the activity level of NF-kappaB contributes, as a secondary effect, to the transcription of heparanase in human colon adenocarcinoma LS-174T cells ... These results suggest that
eIF-4E play an important role in translational regulation of
NF-kappaB expression in LS-174T cells.NF-kappaB is an essential factor in the regulatory mechanisms of heparanase gene transcription, and the suppressed NF-kappaB activity in LS-174T cells may significantly reduce the transcriptional expression of heparanase that consequently leads to decreased heparanase protein expression and enzymatic activity
Rosenwald et al., Hum Pathol 2008
(Hodgkin Disease) :
An increase in
eIF-4E expression may
lead to constitutively high expression of
NFkappaB , a transcription factor implicated in resistance to apoptosis and induction of cytokine gene expression in various cells, including neoplastic cells of HL