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BIRC7 — CASP3
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
BIRC7
—
CASP3
(direct interaction, pull down)
Kasof et al., J Biol Chem 2001*
-
IRef Hprd Interaction:
BIRC7
—
CASP3
(in vitro)
Kasof et al., J Biol Chem 2001*, Vucic et al., Curr Biol 2000*
-
IRef Hprd Interaction:
BIRC7
—
CASP3
(in vivo)
Kasof et al., J Biol Chem 2001*, Vucic et al., Curr Biol 2000*
-
IRef Intact Interaction:
BIRC7
—
CASP3
(physical association, enzymatic study)
Vucic et al., Curr Biol 2000*
-
IRef Ophid Interaction:
BIRC7
—
CASP3
(aggregation, confirmational text mining)
Kasof et al., J Biol Chem 2001*
-
IRef Ophid Interaction:
BIRC7
—
CASP3
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Kasof et al., J Biol Chem 2001
:
In addition, the unprocessed and cleaved forms of caspase-9 co-immunoprecipitated with Livin in vivo, and recombinant
Livin could
inhibit the activation of
caspase-9 induced by Apaf-1, cytochrome c, and dATP
Vucic et al., J Biol Chem 2002
:
Here we show that melanoma IAP
(ML-IAP) , a potent anti-cell death protein and
caspase inhibitor , physically interacts with SMAC through its BIR ( baculovirus IAP repeat ) domain
Yan et al., J Dermatol Sci 2006
(Melanoma) :
Proteolytic cleavage of
Livin ( ML-IAP ) in apoptotic melanoma cells potentially
mediated by a non-canonical
caspase
Das et al., Cancer 2007
(Glioblastoma) :
Other events in apoptosis included overexpression of Bax, down-regulation of Bcl-2 and some
BIRC proteins, mitochondrial release of cytochrome c and Smac into the cytosol, and
activation of calpain,
caspase-9 , and caspase-3
Das et al., Brain Res 2008
(Brain Neoplasms...) :
Besides, apoptosis was associated with alterations in expression of pro-apoptotic Bax and anti-apoptotic Bcl-2 proteins resulting in an increase in Bax : Bcl-2 ratio, mitochondrial release of cytochrome c and Smac, downregulation of selective baculoviral inhibitor-of-apoptosis repeat containing (
BIRC ) molecules, an increase in intracellular free [Ca2+ ], and
activation of calpain and
caspase-3
Karmakar et al., Neuroscience 2009
(Body Weight...) :
Combination of 4-HPR and GST increased Bax : Bcl-2 ratio, mitochondrial release of Smac, downregulation of baculovirus inhibitor-of-apoptosis repeat containing (
BIRC ) proteins including BIRC-2 and BIRC-3, and activation of
caspase-3 and apoptosis
inducing factor ( AIF )
Zhu et al., International journal of molecular sciences 2012
:
Moreover, bufalin synergized with Akt inhibitor to induce the apoptosis of A549 cells and this was associated with the upregulation of Bax expression, the downregulation of Bcl-2 and
livin expression, and the
activation of
Caspase-3
Ding et al., Tumour Biol 2013
(Colonic Neoplasms) :
The stable overexpression of
Livin inhibited the activation of
caspase-3 and led to resistance to cisplatin, while the knockdown of Livin by siRNA rendered colon cancer cells more sensitive to cisplatin