Gene interactions and pathways from curated databases and text-mining

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CTNNB1 — DVL1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Kishida et al., Mol Cell Biol 1999 : Dvl-1 inhibited Axin promoted glycogen synthase kinase 3beta dependent phosphorylation of beta-catenin , and the DIX domain of Dvl-1 was required for this inhibitory activity ... Expression of Dvl-1 in L cells induced the nuclear accumulation of beta-catenin , and deletion of the DIX domain abolished this activity
González-Sancho et al., Mol Cell Biol 2004 : Unlike the effects of Wnt1, phosphorylation of Dvl in response to Wnt5a is not concomitant with beta-catenin stabilization, indicating that Dvl phosphorylation is not sufficient to activate canonical Wnt/beta-catenin signaling
Yau et al., Oncogene 2005 (Carcinoma, Hepatocellular...) : Dishevelled ( Dvl ) , a key activator of the pathway, inhibits the adenomatous polyposis coli complex, and this leads to the accumulation of beta-catenin and promotes tumorigenesis
Bryja et al., Cell Signal 2007 : Thus, our results show that Wnt-3a rapidly induce a partial activation of beta-catenin in the absence of PS-Dvl at low doses, while at high doses induce a full activation of beta-catenin in a PS-Dvl dependent manner
Wei et al., Lung Cancer 2008 (Carcinoma, Non-Small-Cell Lung...) : We also examined the effect of Dvl-1 and Dvl-3 overexpression on beta-catenin expression and the invasive ability of A549 and QG56 lung cancer cells
Zhao et al., Mol Carcinog 2010 (Carcinoma, Non-Small-Cell Lung...) : Dvl-1 overexpression enhanced the Tcf dependent transcriptional activity and beta-catenin expression significantly
Zhang et al., Cell Signal 2010 : Among these, Dishevelled ( Dvl ) is a critical regulator that releases beta-catenin from degradation and stabilizes TCF4/beta-catenin complex