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E2F1 — MYBL2
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Hanada et al., Mol Carcinog 2006
:
Also found in breast tumors with high levels is
B-Myb , a transcription factor whose expression is
activated by
E2F1/3 at the late G1 phase and the level is sustained through the S phase ... As EGFR lacks DNA binding domain but contains transactivational activity and
E2F1 activates
B-Myb expression in the G1/S phase, we further reasoned that nuclear EGFR might cooperate with E2F1 leading to activation of B-Myb ... Consistently, forced expression of both EGFR and
E2F1 in EGFR-null CHO cells greatly
enhanced B-Myb promoter activity, compared to the vector control and expression of EGFR or E2F1 alone ... Promoter mutagenesis studies showed that EGF induced activation of
B-Myb promoter
required both
E2F and EGFR target sites
Nakajima et al., Hepatology research : the official journal of the Japan Society of Hepatology 2008
:
Activation of
B-Myb by
E2F1 in hepatocellular carcinoma
Sahin et al., International journal of biological sciences 2010
:
For example,
E2F-1 acts as part of the repression complex with pRB in the expression of DHFR,
b-myb , TK and cdc2 in asynchronously growing cells ; on the other hand, E2F-1 acts as an activator in the expression of the same genes in cells that are re-entering the cycle ... For example,
E2F-1 acts as part of the repression complex with pRB in the expression of DHFR,
b-myb , TK and cdc2 in asynchronously growing cells ; on the other hand, E2F-1 acts as an activator in the expression of the same genes in cells that are re-entering the cycle
Lam et al., Gene 1995
:
We demonstrate here that activity of the human
B-myb promoter is
regulated during the cell cycle by the
E2 transcription factor ( E2F )
Lyon et al., Crit Rev Oncog 1994
(Neoplasms) :
Consistent with this conclusion,
B-myb transcription is
controlled by the transcription factor
E2F , which has been implicated in cell cycle regulation of a number of genes involved in DNA synthesis
Lam et al., EMBO J 1993
:
An
E2F binding site mediates cell-cycle
regulated repression of mouse
B-myb transcription
Bennett et al., Oncogene 1996
:
E2F binding is
required but not sufficient for repression of
B-myb transcription in quiescent fibroblasts