Crandall et al., Biochem Biophys Res Commun 2000
:
Release of PAI-1 by human preadipocytes and adipocytes independent of insulin and IGF-1 ... Insulin and IGF-1 over a range of concentrations had no effect on PAI-1 release, and RT-PCR of PAI-1 mRNA following treatment with insulin and IGF-1 also indicated similar expression between treatments
Dimova et al., Thromb Haemost 2005
(MAP Kinase Signaling System...) :
We found that IGF-1 induced up-regulation of PAI-1 expression was associated with activation of HIF-1 alpha ... Thus, IGF-1 activates human PAI-1 gene expression through activation of the PI3-kinase and ERK1/2 via HIF-1alpha