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ACACB — PRKAG2

Pathways - manually collected, often from reviews:

• KEGG Insulin signaling pathway: PRKAA1/PRKAA2/PRKAB1/PRKAB2/PRKAG1/PRKAG2/PRKAG3 → ACACA/ACACB (protein-protein, inhibition)
• KEGG Adipocytokine signaling pathway: PRKAA1/PRKAA2/PRKAB1/PRKAB2/PRKAG1/PRKAG2/PRKAG3 → ACACB (protein-protein, inhibition)
• Reactome Reaction: PRKAG2 → ACACB (reaction) Ruderman et al., Nat Rev Drug Discov 2004*
• WikiPathways AMP-activated Protein Kinase (AMPK) Signaling: Complex of PRKAG3-PRKAA1-PRKAG2-PRKAG1-PRKAB2-PRKAB1-PRKAA2 → ACACA/ACACB (mim-inhibition)

Text-mined interactions from Literome

Chen et al., J Clin Endocrinol Metab 2005 (Diabetes Mellitus, Type 2...) : In obese myotubes, the activation of AMPK signaling by gAD at low concentrations ( 0.1 mug/ml ) was blunted, but higher concentrations ( 0.5 mug/ml ) stimulated AMPKalpha1 and -alpha2 activities, AMPK and ACCbeta phosphorylation, and fatty acid oxidation
Birk et al., J Physiol 2006 : Previous studies describe discrepancies between total AMPK activity and regulation of its target acetyl-CoA-carboxylase (ACC)beta
Adam et al., Biochem Biophys Res Commun 2010 : AMPK inhibits ACCbeta activity, lowering malonyl-CoA levels and promoting mitochondrial fatty acid beta-oxidation ... AMPK activation dose-dependently reduced ACCbeta promoter activity, while NRF-1 addition did not further decrease it ... Our data extends AMPK regulation of ACCbeta to the transcriptional level