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MAP3K5 — TXN

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MAP3K5 → TXN (decreases, TXN Activity) Song et al., Biochem J 2003*
  Evidence: Redox-sensing molecules such as thioredoxin (TRX) and glutaredoxin (GRX) bind to apoptosis signal-regulating kinase 1 (ASK1) and suppress its activation
• OpenBEL Selventa BEL large corpus: MAP3K5 → Complex of MAP3K5-TXN (decreases, MAP3K5/TXN Activity) Song et al., Biochem J 2003*
  Evidence: Redox-sensing molecules such as thioredoxin (TRX) and glutaredoxin (GRX) bind to apoptosis signal-regulating kinase 1 (ASK1) and suppress its activation
• NCI Pathway Database p38 MAPK signaling pathway: TRAF2 (TRAF2) → TRX/ASK1 complex (MAP3K5-TXN) (modification, collaborate)
  Liu et al., Mol Cell Biol 2000*, Noguchi et al., J Biol Chem 2005*, Saitoh et al., EMBO J 1998, Nishitoh et al., Mol Cell 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database p38 MAPK signaling pathway: thioredoxin (TXN) → TRX/ASK1 complex (MAP3K5-TXN) (modification, collaborate)
  Liu et al., Mol Cell Biol 2000*, Noguchi et al., J Biol Chem 2005*, Saitoh et al., EMBO J 1998, Nishitoh et al., Mol Cell 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database p38 MAPK signaling pathway: thioredoxin (TXN) → TRAF2/ASK1 complex (TRAF2-MAP3K5) (modification, collaborate)
  Liu et al., Mol Cell Biol 2000*, Noguchi et al., J Biol Chem 2005*, Saitoh et al., EMBO J 1998, Nishitoh et al., Mol Cell 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database p38 MAPK signaling pathway: TRX/ASK1 complex (MAP3K5-TXN) → TRAF2/ASK1 complex (TRAF2-MAP3K5) (modification, collaborate)
  Liu et al., Mol Cell Biol 2000*, Noguchi et al., J Biol Chem 2005*, Saitoh et al., EMBO J 1998, Nishitoh et al., Mol Cell 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database TNF receptor signaling pathway : ASK1 (MAP3K5) → TRX/ASK1 complex (MAP3K5-TXN) (modification, collaborate)
  Ichijo et al., Science 1997, Saitoh et al., EMBO J 1998, Nishitoh et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database TNF receptor signaling pathway : ASK1 (MAP3K5) → thioredoxin (TXN) (modification, collaborate) Ichijo et al., Science 1997, Saitoh et al., EMBO J 1998, Nishitoh et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database TNF receptor signaling pathway : sTNF-alpha/TNFR1A/TRADD/TRAF2 complex (TNFRSF1A-TRADD-TRAF2-TNF) → TRX/ASK1 complex (MAP3K5-TXN) (modification, activates)
  Ichijo et al., Science 1997, Saitoh et al., EMBO J 1998, Nishitoh et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database TNF receptor signaling pathway : TRX/ASK1 complex (MAP3K5-TXN) → thioredoxin (TXN) (modification, collaborate) Ichijo et al., Science 1997, Saitoh et al., EMBO J 1998, Nishitoh et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database p38 MAPK signaling pathway: TRAF6 (TRAF6) → TRX/ASK1 complex (MAP3K5-TXN) (modification, collaborate)
  Matsuzawa et al., Nat Immunol 2005*, Noguchi et al., J Biol Chem 2005*, Saitoh et al., EMBO J 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database p38 MAPK signaling pathway: thioredoxin (TXN) → TRX/ASK1 complex (MAP3K5-TXN) (modification, collaborate)
  Matsuzawa et al., Nat Immunol 2005*, Noguchi et al., J Biol Chem 2005*, Saitoh et al., EMBO J 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database p38 MAPK signaling pathway: thioredoxin (TXN) → TRAF6/ASK1 complex (TRAF6-MAP3K5) (modification, collaborate)
  Matsuzawa et al., Nat Immunol 2005*, Noguchi et al., J Biol Chem 2005*, Saitoh et al., EMBO J 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database p38 MAPK signaling pathway: TRX/ASK1 complex (MAP3K5-TXN) (modification, collaborate) Matsuzawa et al., Nat Immunol 2005*, Noguchi et al., J Biol Chem 2005*, Saitoh et al., EMBO J 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database p38 MAPK signaling pathway: TRX/ASK1 complex (MAP3K5-TXN) → TRAF6/ASK1 complex (TRAF6-MAP3K5) (modification, collaborate)
  Matsuzawa et al., Nat Immunol 2005*, Noguchi et al., J Biol Chem 2005*, Saitoh et al., EMBO J 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• Reactome Reaction: MAP3K5 → TXN (direct_complex)
• Reactome Reaction: MAP3K5 → TXN (reaction) Nicke et al., Mol Cell 2005*, Saitoh et al., EMBO J 1998

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: MAP3K5 — TXN Song et al., J Biol Chem 2002*
• IRef Bind_translation Interaction: MAP3K5 — TXN (coimmunoprecipitation) Song et al., J Biol Chem 2002*
• IRef Biogrid Interaction: MAP3K5 — TXN (physical association, affinity chromatography technology) Morita et al., EMBO J 2001*
• IRef Biogrid Interaction: MAP3K5 — TXN (direct interaction, two hybrid) Saitoh et al., EMBO J 1998
• IRef Biogrid Interaction: MAP3K5 — TXN (physical association, affinity chromatography technology) Saitoh et al., EMBO J 1998
• IRef Biogrid Interaction: MAP3K5 — TXN (direct interaction, pull down) Saitoh et al., EMBO J 1998
• IRef Biogrid Interaction: MAP3K5 — TXN (physical association, affinity chromatography technology) Fujino et al., Mol Cell Biol 2007*
• IRef Biogrid Interaction: MAP3K5 — TXN (direct interaction, two hybrid) Fujino et al., Mol Cell Biol 2007*
• IRef Biogrid Interaction: MAP3K5 — TXN (physical association, affinity chromatography technology) Görner et al., J Biol Chem 2007*
• IRef Biogrid Interaction: MAP3K5 — TXN (physical association, affinity chromatography technology) Im et al., Neurosci Res 2010*
• IRef Biogrid Interaction: MAP3K5 — TXN (physical association, affinity chromatography technology) Junn et al., J Immunol 2000*
• IRef Biogrid Interaction: MAP3K5 — TXN (direct interaction, pull down) Liu et al., Circ Res 2002*
• IRef Biogrid Interaction: MAP3K5 — TXN (physical association, affinity chromatography technology) Liu et al., Circ Res 2002*
• IRef Dip Interaction: Complex of TXN-CIB1-MAP3K5 (anti bait coimmunoprecipitation) Yoon et al., Proc Natl Acad Sci U S A 2009*
• IRef Dip Interaction: MAP3K5 — TXN (physical association, anti bait coimmunoprecipitation) Yoon et al., Proc Natl Acad Sci U S A 2009*
• IRef Hprd Interaction: MAP3K5 — TXN (in vitro) Liu et al., Circ Res 2002*, Saitoh et al., EMBO J 1998
• IRef Hprd Interaction: MAP3K5 — TXN (in vivo) Liu et al., Circ Res 2002*, Saitoh et al., EMBO J 1998
• IRef Hprd Interaction: MAP3K5 — TXN (two hybrid) Liu et al., Circ Res 2002*, Saitoh et al., EMBO J 1998
• IRef Intact Interaction: Complex of MAP3K5-ZNF622-TXN (association, anti bait coimmunoprecipitation) Seong et al., J Biol Chem 2011*
• IRef Intact Interaction: MAP3K5 — TXN (physical association, anti bait coimmunoprecipitation) Seong et al., J Biol Chem 2011*
• IRef Ophid Interaction: MAP3K5 — TXN (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Song et al., Biochem J 2003 : Differential role of glutaredoxin and thioredoxin in metabolic oxidative stress induced activation of apoptosis signal regulating kinase 1
Lim et al., Toxicological sciences : an official journal of the Society of Toxicology 2008 : This was followed by a shift of the redox ratio of mitochondrial Trx2 toward the oxidized state and subsequent activation of Ask1 ... Mito-CP not only decreased troglitazone induced superoxide levels but also prevented Trx2 oxidation and activation of Ask1 and protected cells from toxic injury
Yang et al., Free Radic Biol Med 2011 : Lowering TRX-1 or TRX-2 in E47 cells caused an early activation of ASK-1 , followed by phosphorylation of JNK1 after 48 h of siRNA treatment
Sheng et al., Mol Med Report 2013 : H2O2 promoted VSMC apoptosis, ASK-1 protein expression increased and Trx-l protein expression decreased