Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
Complex of ICAM1-ITGAM-ITGB2
→
SPN
(decreases, ICAM1/ITGAM/ITGB2 Activity)
Evidence: Neutrophils are partially activated (primed) by the TNF and leukotrienes produced by mast cells and by other neutrophils, leading to release of small amounts of elastase. This cleaves the anti-adhesive coat of CD43 (leukosialin) from neutrophils, allowing their integrins to engage extracellular matrix proteins.