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IL6 — MPO

Text-mined interactions from Literome

Altavilla et al., Life Sci 2000 (Coronary Disease...) : Myocardial ischaemia plus reperfusion in untreated rats produced marked myocardial necrosis, increased serum CPK activity ( 196.5 +/- 19 U/100 ml, at the end of reperfusion ) and myeloperoxidase activity ( MPO, a marker of leukocyte accumulation ) both in the area-at-risk ( 4.5 +/- 0.5 U/g/tissue ) and in necrotic area ( 8.2 +/- 1.2 U/g/tissue ), reduced myocardial contractility ( 1,706 +/- 52 mmHg/s, at the end of reperfusion ) and induced a marked increase in the serum levels of TNF-alpha ( 1,950 +/- 97 pg/ml, at 1 h of reperfusion ) and IL-6 ( 998 +/- 16 U/ml, at the end of reperfusion )
Yang et al., J Mol Cell Cardiol 2006 (Shock, Hemorrhagic...) : Thus, IL-6 mediated upregulation of cardiac NF-small ka, CyrillicB, ICAM-1, CINC-1, -3, and MPO activity likely contributes to altered cardiac function following T-H and neutralization of IL-6 therefore appears to be an effective and novel adjunct for improving organ/cell function under those conditions
Qian et al., Am J Chin Med 2006 (Acute Disease...) : Shen-Fu ( 10,100 mg/kg ) decreased MPO activity and wet/dry weight ratio and inhibited TNF-alpha and IL-6 production, endotoxin induced NF-kappa B activation
Yang et al., J Mol Cell Cardiol 2007 (Disease Models, Animal...) : Thus, IL-6 mediated up-regulation of cardiac NF-kappaB, ICAM-1, CINC-1, -3, and MPO activity likely contributes to altered cardiac function following trauma-hemorrhage
Lin et al., J Am Soc Nephrol 2008 (Acute Kidney Injury...) : Measures of inflammation ( number of infiltrating neutrophils, myeloperoxidase activity, and induction of IL-6 and P-selectin ) and activation of NF-kappaB were lower in GC-G ( -/- ) mice compared with wild-type mice
Lee et al., Inflammation 2009 (Colitis) : The TNBS treatment caused colon shortening, increased myeloperoxidase activity, induced IL-1beta, TNF-alpha, and IL-6 expression in the colon, activated NF-kappaB, and potentiated the GAG degrading activities of intestinal microflora
Liu et al., J Ethnopharmacol 2011 (Colitis) : IG significantly ameliorated macroscopic damage and histological changes, reduced the activity of MPO , depressed MDA and NO levels and effectively inhibited the protein and mRNA expressions of NF-?Bp65, TNF-a and IL-6 in the colon tissues of experimental colitis in a dose dependent manner