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EGF — PAPSS1

Text-mined interactions from Literome

Döll et al., Biochim Biophys Acta 2005 (Breast Neoplasms...) : Mechanistically, the transcriptional upregulation is dependent on the classical mitogen activated protein kinase, protein kinase C ( PKC ) and the phosphoinositide 3-kinase, since specific inhibitors of these enzymes all abolish the EGF induced mRNA upregulation and activity of SK-1 ... Moreover, dexamethasone also suppressed EGF induced SK-1 mRNA expression and activity which is reversed by the glucocorticoid receptor antagonist RU486 ... To see whether EGF induced upregulation of SK-1 is of relevance for tumor progression, we investigated two hallmarks of carcinogenesis, i.e., cell proliferation and migration ... In summary, these data show that EGF causes an acute stimulation of SK-1 activity and, moreover, triggers a delayed SK activation which is due to increased gene transcription and de novo synthesis of SK-1, which in turn directs cells towards growth and increased motility
Long et al., Mol Cell Biol 2010 (Breast Neoplasms) : We demonstrate here a new concept termed `` oncogene tolerance '' whereby human EGF receptor 2 ( HER2 ) increases sphingosine kinase 1 (SK1) expression in estrogen receptor positive ( ER ( + ) ) MCF-7 HER2 cells and SK1, in turn, limits HER2 expression in a negative-feedback manner