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EGF — NFKBIA
Text-mined interactions from Literome
Banan et al., J Pharmacol Exp Ther 2003
:
2 )
EGF ( 10 ng/ml )
stabilized I-kappaBalpha and prevented both NF-kappaB translocation and activation while protecting monolayers against oxidants
Anest et al., J Biol Chem 2004
:
Here we show that
EGF treatment of quiescent fibroblast does not
induce the classical pathway of NF-kappaB activation through IkappaB kinase (IKK) directed
IkappaBalpha phosphorylation
Duncan et al., J Biol Chem 2006
:
Furthermore, MSK1/2 control
EGF induced
IkappaB alpha promoter H3-Ser10 phosphorylation in the absence of elevated transcription
Sethi et al., Oncogene 2007
(Adenocarcinoma...) :
By using specific antibodies and IkappaBalpha plasmid, which is mutated at tyrosine 42 to phenylalanine, we show that
EGF induced the tyrosine phosphorylation of
IkappaBalpha at residue 42 ... Furthermore,
EGF receptor kinase inhibitor
blocked IkappaBalpha phosphorylation and consequent NF-kappaB activation
Sun et al., Oncogene 1998
:
Also, Bapta A/M ( a cell-permeable chelator of intracellular calcium ) blocks
EGF induced NF-kappa-B activation and
IkappaBalpha degradation, suggesting a requirement of intracellular free Ca2+ for this growth factor response