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CPOX — EGF
Text-mined interactions from Literome
Kajanne et al., Pediatr Res 2007
:
We tested the
effect of
EGF , hydrocortisone, and indomethacin on its activation, cell proliferation and migration,
COX-2 expression, and prostaglandin E2 ( PGE2 ) production
Jia et al., Zhonghua Nan Ke Xue 2008
:
To investigate the effect of PI-3K and p38MAPK signal pathways on the
cyclooxygenase-2 (COX-2) expression
induced by the
epidermal growth factor (EGF) in PC-3 cells
Sabri et al., Cell Biochem Funct 2011
(MAP Kinase Signaling System) :
Furthermore,
EGF induced proliferation as well as EGF augmented
COX2 expression was hindered by ERK1/2 and p38 inhibitors
Bany et al., Biol Reprod 1995
:
In addition to IL-1 alpha,
epidermal growth factor ( EGF, 40 ng/ml ) also
caused a significant increase in PGE2 accumulation in the medium and
COX activity in the cells ... The combined
effects of IL-1 alpha and
EGF on PGE2 accumulation and
COX activity were additive
Sato et al., Prostaglandins 1997
(Carcinoma, Squamous Cell) :
In addition, Northern blot analysis showed that the level of COX-2 mRNA was increased by the EGF-treatment, whereas no COX-2 mRNA was detected in the untreated cells, indicating that the
EGF induced
COX activity was resulted from the increase in the production of COX-2