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CXCL12 — PXN
Pathways - manually collected, often from reviews:
-
NCI Pathway Database CXCR4-mediated signaling events:
SDF1/CXCR4/JAK2 complex (CXCL12-CXCR4-JAK2)
→
Paxillin (PXN)
(modification, activates)
Wang et al., Blood 2000, Zhang et al., Blood 2001, Okabe et al., J Hematother Stem Cell Res 2002, Le et al., J Immunol 2005
Evidence: mutant phenotype, assay, physical interaction
Text-mined interactions from Literome
Cohen-Hillel et al., Cell Mol Life Sci 2009
:
In this study, we found that
CXCL8 stimulation
led to
paxillin phosphorylation in normal neutrophils, and that both CXCL8 receptors ( CXCR1 and CXCR2 ) mediated CXCL8 induced paxillin phosphorylation
Gao et al., Stem Cells 2009
:
Furthermore, stimulation of hMSCs with recombinant
SDF-1 and tumor cell conditioned medium also significantly
activated the focal adhesion kinases ( FAKs ) and
paxillin , which correlated with reorganization of F-actin filaments in hMSCs
Ganju et al., J Biol Chem 1998
:
Wortmannin, a selective inhibitor of phosphatidylinositol 3-kinase, partially inhibited the
SDF-1alpha induced migration and tyrosine phosphorylation of
paxillin