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BTRC — NEDD8

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: BTRC — NEDD8 (physical association, affinity chromatography technology) Read et al., Mol Cell Biol 2000
• IRef Biogrid Interaction: BTRC — NEDD8 (physical association, affinity chromatography technology) Schweitzer et al., EMBO J 2007*
• MIPS CORUM Ubiquitin E3 ligase (CDC34, NEDD8, BTRC, CUL1, SKP1A, RBX1): Ubiquitin E3 ligase (CDC34, NEDD8, BTRC, CUL1, SKP1A, RBX1) complex (BTRC-CUL1-NEDD8-RBX1-SKP1) Read et al., Mol Cell Biol 2000
• IRef Corum Interaction: Complex of CUL1-SKP1-RBX1-NEDD8-BTRC (association, anti tag coimmunoprecipitation) Read et al., Mol Cell Biol 2000
• IRef Hprd Interaction: Complex of 37 proteins (in vivo) Read et al., Mol Cell Biol 2000
• IRef Innatedb Interaction: Complex of BTRC-CUL1-NEDD8 (unknown, -) Read et al., Mol Cell Biol 2000
• IRef Intact Interaction: Complex of 35 proteins (association, anti tag coimmunoprecipitation) Jäger et al., Nature 2012
• IRef Intact Interaction: BTRC — NEDD8 (physical association, anti bait coimmunoprecipitation) Schweitzer et al., EMBO J 2007*

Text-mined interactions from Literome

Read et al., Mol Cell Biol 2000 : The site of Nedd8 ligation to Cul-1 is essential, as SCF(beta(TrCP)) containing a K720R mutant of Cul-1 only weakly supported IkappaBalpha ubiquitination compared to SCF(beta(TrCP)) containing WT Cul-1, suggesting that the Nedd8 ligation of Cul-1 affects the ubiquitination activity of SCF(beta(TrCP))
Tanaka et al., Biochimie 2001 : In this NF-kappaB signalling pathway, it becomes clear that the SCF ( Fbw1 ) activity is enhanced by a ubiquitin-like protein NEDD8 ( equivalent to Rub1 ) that modifies Cul-1 in a manner analogous to ubiquitylation, and consequently, IkappaBalpha proteolysis is induced