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ATP5O — PGP

Text-mined interactions from Literome

Fujino et al., Drug Metab Pharmacokinet 2002 : In view of the widespread clinical use of pitavastatin and the importance of drug-drug interaction, the inhibitory effect on Pgp mediated activation of ATPase was also investigated ... Moreover, no inhibitory effect on the Pgp mediated activation of ATPase by verapamil was found in the presence of pitavastatin over a wide concentration range
El-Masry et al., J Toxicol Environ Health 2006 : DEET was also found to be a potent inhibitor of P-gp mediated ATPase activity, whereas pyridostigmine bromide increased P-gp ATPase activity
Rao et al., Int J Oncol 2006 (Adenocarcinoma...) : Co-expression of RNF2 with Pgp in Sf9 insect cells resulted in decreased ATPase activity and proteolytic protection of the transporter protein
Kitagawa et al., Biol Pharm Bull 2007 : Analysis of verapamil stimulated ATPase activity in membrane vesicles expressing human P-gp suggested that the increased daunorubicin accumulation by M4 was at least partly due to ATPase inhibition of P-gp
Doublier et al., Mol Cancer Res 2008 (Colonic Neoplasms) : Moreover, RhoA silencing decreased the ATPase activity of P-glycoprotein (Pgp) in HT29 and HT29-dx cells as a consequence of the reduced expression of Pgp
Vaidya et al., Mol Pharm 2009 : DNP-SG efflux decreased by 69.1 ( +/-11.3 ) %, 51.1 ( +/-5.4 ) %, 56.7 ( +/-8.3 ) % and 53.6 ( +/-10.8 ) % ( p < 0.05 ) in the presence of 5 mM sodium orthovanadate ( ATPase inhibitor ), 100 microM MK571 ( MRP-inhibitor ), 1 mM dipyridamole ( BCRP/P-gp/MRP1-inhibitor ) and 100 microM verapamil ( P-gp/MRP1 inhibitor ) respectively, without any change in DNP-SG formation, total tissue glutathione, GSH/GSSG ratio, tissue integrity or tissue viability
Ji et al., Pharmazie 2010 : Kinetic analysis indicated a noncompetitive inhibition of Ver stimulated P-gp ATPase activity and a competitive inhibition of CJX2 stimulated P-gp ATPase activity by CJZ3, moreover, the effect of CsA on CJZ3 stimulated and Ver stimulated P-gp ATPase activity showed a non-competitive and a competitive inhibition respectively
Hung et al., PloS one 2013 : Methadone also stimulated P-gp ATPase and inhibited verapamil stimulated P-gp ATPase activity under therapeutic concentrations
Lanning et al., J Toxicol Environ Health 1996 : To correlate the binding of chlorpyrifos oxon to P-gp with a biochemical effect, we examined its ability to stimulate P-gp mediated ATPase activity in these Sf9 cells
Regev et al., Eur J Biochem 1999 : The mode of inhibition, i.e. lack of evidence for classical enzyme inhibition and the correlation of Pgp ATPase inhibition with membrane fluidization over a wide range of concentrations and structures of drugs favors the direct inhibition of Pgp ATPase activity by membrane fluidization