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RHOA — RICTOR

Pathways - manually collected, often from reviews:

• NCI Pathway Database mTOR signaling pathway: mTORC2 complex (MTOR-MLST8-RICTOR-MAPKAP1-PRR5) → RHOA/GTP complex (RHOA) (regulation of actin cytoskeleton organization, activates) Sarbassov et al., Curr Biol 2004, Jacinto et al., Nat Cell Biol 2004
  Evidence: mutant phenotype

Text-mined interactions from Literome

Goncharova et al., Mol Cell Biol 2011 : Our data demonstrate that mTORC2 dependent activation of RhoA is required for TSC2-null cell growth and survival and suggest that targeting both mTORC2 and mTORC1 by a combination of proapoptotic simvastatin and cytostatic rapamycin shows promise for combinational therapeutic intervention in diseases with TSC2 dysfunction
Back et al., Photochem Photobiol 2012 (Carcinoma, Squamous Cell...) : Exogenous overexpression of Rictor restores RhoA-GTPase activity and actin cytoskeleton network, and decreases resveratrol induced senescence associated ß-gal activity, indicating a direct role of Rictor in senescence induction