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RACGAP1 — RHOA

Pathways - manually collected, often from reviews:

• NCI Pathway Database Aurora B signaling: Centraspindlin complex (KIF23-RACGAP1) → RHOA/GTP complex (RHOA) (modification, activates) Minoshima et al., Dev Cell 2003*
  Evidence: mutant phenotype, assay
• NCI Pathway Database Aurora B signaling: Centraspindlin complex (KIF23-RACGAP1) → RHOA/GDP complex (RHOA) (modification, activates) Minoshima et al., Dev Cell 2003*
  Evidence: mutant phenotype, assay
• Reactome Reaction: RHOA → RACGAP1 (reaction) Richnau et al., J Biol Chem 2001, Krugmann et al., Mol Cell 2002, Tcherkezian et al., Biol Cell 2007, Fainstein et al., Nature 1987, Lancaster et al., J Biol Chem 1994, Yuan et al., Cancer Res 1998
• WikiPathways Wnt Signaling Pathway and Pluripotency: DVL3/DVL2/DVL1 → Complex of RACGAP1-RHOA (mim-stimulation)
• WikiPathways Wnt Signaling Pathway and Pluripotency: Complex of RACGAP1-RHOA → MAPK10/MAPK9 (mim-stimulation)

Text-mined interactions from Literome

Naud et al., Biochem J 2003 : Whereas MgcRacGAP was found only in spermatocytes and early spermatids, the widespread RhoGTPases RhoA , Rac1 and Cdc42 ( which are, to various extents, in vitro substrates for MgcRacGAP activity ) were, surprisingly, not detected at these stages
Liot et al., PloS one 2011 : RhoA GDP/GTP cycling is required for normal cytokinesis and recent reports have shown that the exchange factor Ect2 and the GTPase activating protein MgcRacGAP regulate RhoA activity during mitosis
Tse et al., Mol Biol Cell 2012 : RhoA activation during polarization and cytokinesis of the early Caenorhabditis elegans embryo is differentially dependent on NOP-1 and CYK-4