◀ Back to BCL2

BCL2 — KEAP1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: KEAP1 — BCL2 (physical association, affinity chromatography technology) Niture et al., Cell Death Differ 2011*
• IRef Biogrid Interaction: KEAP1 — BCL2 (direct interaction, enzymatic study) Niture et al., Cell Death Differ 2011*
• IRef Biogrid Interaction: KEAP1 — BCL2 (colocalization, imaging technique) Niture et al., Cell Death Differ 2011*

Text-mined interactions from Literome

Niture et al., J Biol Chem 2011 : Overexpression of PGAM5 protein increased INrf2 mediated degradation of Bcl-xL , whereas knocking down PGAM5 by siRNA decreased INrf2 degradation of Bcl-xL, resulting in increased stability of Bcl-xL
Tian et al., Cancer Lett 2012 (Neoplasms) : Keap1 led to the repression and destabilization of Bcl-2 , decreased Bcl-2 : Bax heterodimers and facilitated cancer cells apoptosis