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PLD1 — WNT11
Text-mined interactions from Literome
Kang et al., Cancer Res 2010
(Neoplasms) :
PLD1 expression and activity was enhanced by treatment with Wnt3a and glycogen synthase kinase-3 inhibitors, and the
Wnt pathway regulated transcription factors beta-catenin and TCF-4 were
required for this effect
Kang et al., PloS one 2010
(Colorectal Neoplasms...) :
Suppressing
PLD using gene silencing or selective inhibitor
blocked the ability of beta-catenin to transcriptionally activate PLD and other
Wnt target genes by preventing formation of the beta-catenin/TCF-4 complex, whereas tactics to elevate intracellular levels of phosphatidic acid, the product of PLD activity, enhanced these effects