Davey et al., Tissue Antigens 2006
:
In addition, SOCS1 has a complex role in T cell activation, and studies have revealed significant roles for SOCS1 in the regulation of IL-4, IL-12 and IL-15 in vivo
Zhang et al., J Immunol 2011
(Hepatitis C, Chronic) :
Conversely, silencing SOCS-1 expression using small interfering RNAs increased IL-12 expression and inhibited PD-1 upregulation