DeGroot et al., Osteoarthritis Cartilage 2001
:
This study shows that an increase in AGE levels negatively affects the proteoglycan synthesis and degradation of articular cartilage
Huang et al., Rheumatology (Oxford) 2011
(Osteoarthritis) :
Inhibition of JAK2 or JAK3 prevented AGE mediated decrease of collagen II in chondrocytes and proteoglycan ( aggrecan ) degradation in cartilage fragments ... Blocking JAK/STAT3 signalling pathway inhibited AGE induced activation of MMP-13 and ADAMTS and prevented AGE mediated decrease of collagen II and proteoglycan ( aggrecan )